SPRR1B Antibody, FITC conjugated
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中文名稱：SPRR1B兔多克隆抗體, FITC偶聯
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貨號：CSB-PA022611LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SPRR1B Polyclonal antibody
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Uniprot No.：
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基因名：SPRR1B
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別名：14.9 kDa pancornulin antibody; Cornifin antibody; Cornifin B antibody; Cornifin-B antibody; CornifinB antibody; GADD33 antibody; MGC61901 antibody; Small proline rich protein IB antibody; Small proline-rich protein IB antibody; SPR-IB antibody; SPR1B_HUMAN antibody; SPRIB antibody; SPRR1 antibody; SPRR1B antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Cornifin-B protein (1-89AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
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基因功能參考文獻：
- Expression of SPRR1 and of SPRR2A is increased in mucosal samples from patients with chronic rhinosinusitis and appeared as a downstream result of TNF alpha modulation, which possibly resulted in epithelial barrier dysfunction. PMID: 28859701
- Levels SPRR1B proteins were significantly higher in AD skin compared with the levels of these proteins in the skin of healthy subjects. PMID: 27304082
- expression of SPRR1B is upregulated in oral CSCs/CICs and SPRR1B has a role in cell growth by suppression of RASSF4 PMID: 23954638
- BMK1 (ERK5) regulates squamous differentiation marker SPRR1B transcription in Clara-like H441 cells. PMID: 12091247
- SPRR1B expression pattern in nonsquamous tumors; findings indicate SPRR1B likely coupled to signals responsible for withdrawal from the proliferative state; overexpression for prolonged periods may disrupt normal progression of mitosis PMID: 12832281
- SPRR1B is a valid biomarker for the study of the molecular mechanisms of squamous metaplasia. There is a definitive link between inflammation and squamous metaplasia in autoimmune-mediated dry eye disease PMID: 18172072
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亞細胞定位：Cytoplasm.
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蛋白家族：Cornifin (SPRR) family
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組織特異性：Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
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數據庫鏈接：
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