SPARCL1 Antibody

說明書

中文名稱：

SPARCL1兔多克隆抗體
貨號：

CSB-PA945237
規格：

￥1090
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SPARCL1 Polyclonal antibody
Uniprot No.：

Q14515
基因名：

SPARCL1
別名：

Ecm2 antibody; Extracellular matrix protein 2 antibody; Hevin antibody; High endothelial venule protein antibody; MAST 9 antibody; mast9 antibody; Matrix glycoprotein Sc1 antibody; PIG33 antibody; proliferation inducing protein 33 antibody; RAGS1 antigen antibody; SC1 antibody; SPARC like 1 antibody; SPARC-like protein 1 antibody; Sparcl1 antibody; SPRL1_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

SPARC-like protein 1 (High endothelial venule protein) (Hevin) (MAST 9)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, ELISA: WB:1:500-2000, ELISA:1:5000-20000
Protocols：

Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. SC1 levels were independently associated with ischemic stroke severity evaluated by the NIHSS. PMID: 29102542
2. The results of this study suggest that the SPARCL1 accelerates Alzheimer's Disease pathogenesis and thus link neuroinflammation with widespread changes in brain structure and function during aging. PMID: 29154276
3. The present study demonstrated that the expression of SPARCL1 was downregulated in renal cell carcinoma (RCC) cells and tissues, however, the overexpression of SPARCL1 inhibited RCC cell migration and invasion. PMID: 28944877
4. This study demonstrated the SPARCL1-containing neurons in the human brainstem and sensory ganglion. PMID: 27357901
5. tumor endothelial cells heterogeneity is regulated by SPARCL1, which promotes the cell quiescence and vessel homeostasis contributing to the favorable prognoses associated with Th1-tumor microenvironments colorectal carcinomas. PMID: 27721236
6. SPARCL1 is involved in the tumorigenesis of hilar cholangiocarcinoma and may serve as a novel molecular biomarker for patients' outcome. PMID: 26490986
7. Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression PMID: 26294211
8. SPARCL1 expression did not inhibit tumor cell proliferation in vitro. By contrast, SPARCL1 did suppress tumor cell migration and invasiveness in vitro and tumor metastatic growth in vivo, conferring improved survival in xenograft mouse models PMID: 23916135
9. radiotherapy causes an increase in SPARCL1 expression; SPARCL1 may have a role in survival in rectal cancer patients PMID: 24661672
10. SPARCL1 functions as a tumor suppressor promoting differentiation possibly via MET, which inhibits the aggressiveness of colorectal cancers PMID: 22891198
11. Sparc-like protein 1 expression correlates with glioma grade, suggesting the possible role for this protein in the progression of this malignancy. PMID: 22909274
12. SPARCL1 is a potent regulator of cell migration/invasion and its loss is independently associated with prostate cancer recurrence. PMID: 22927397
13. Data suggest that the expression of SPARCL1 protein might be a valuable biomarker for early diagnosis in colorectal cancers and further predicting patients' prognosis. PMID: 21887554
14. Down-regulated SPARCL1 is associated with gastric cancer. PMID: 22161898
15. Data suggest that SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in colorectal cancer. PMID: 21528083
16. Overall, these results suggested that the C-t of hevin contains important determinants for interaction with myocilin. PMID: 16316624
17. hevin can modulate the structure of dermal extracellular matrix, specifically by its regulation of decorin levels and collagen fibril assembly PMID: 16844696
18. Despite proteomic studies in CSF from MS patients suggested an important role for SPARCL1 in the development of the disease, SPARCL1 gene does not appear to act as susceptibility factor for MS in the population investigated here. PMID: 17825989
19. A transgenic mouse model in which SPARCL1 is expressed in radial glia provides a novel in vivo system for evaluating the role of SPARCL1 in brain development and function. PMID: 18381651
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

SPARC family
組織特異性：

Highly expressed in lymph node, brain, heart, lung, skeletal muscle, ovary, small intestine, and colon, with lower levels in placenta, pancreas, testis, spleen, and thymus, and no expression in kidney, liver, and peripheral blood leukocytes.
數據庫鏈接：

HGNC: 11220

OMIM: 606041

KEGG: hsa:8404

STRING: 9606.ENSP00000282470

UniGene: Hs.62886

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