SP110 Antibody

說明書

中文名稱：

SP110兔多克隆抗體
貨號：

CSB-PA022440GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HB58
基因名：

SP110
別名：

FLJ22835 antibody; IFI 41 antibody; IFI 75 antibody; IFI41 antibody; IFI75 antibody; Interferon induced protein 41 30kD antibody; Interferon induced protein 41 antibody; Interferon induced protein 41/75 antibody; Interferon induced protein 75 52kD antibody; Interferon induced protein 75 antibody; Interferon-induced protein 41/75 antibody; IPR 1 antibody; IPR1 antibody; Phosphoprotein 41 antibody; Phosphoprotein 75 antibody; SP 110 antibody; SP110 antibody; Sp110 nuclear body protein antibody; SP110_HUMAN antibody; Speckled 110 kDa antibody; Transcriptional coactivator Sp110 antibody; VODI antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human SP110
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
基因功能參考文獻：
1. TNF-alpha -308G>A (rs1800629) showed no association with susceptibility to pulmonary tuberculosis and spinal tuberculosis patients in southern China. PMID: 29430075
2. SP110 polymorphism is associated with tuberculosis. PMID: 27623071
3. Data suggest that Sp110 is sumoylated, de-sumoylated, and then released from the promyelocytic leukemia nuclear bodies in hepatocytes infected with HBV (hepatitis B virus); Sp110 differentially regulates several direct target genes of HBx, a viral co-factor; these mechanisms may be involved in evasion of host immune response by HBV. (Sp110 = Speckled 110 kDa; HBx = hepatitis B virus protein X) PMID: 29046350
4. Using mouse models and genetic characteristics of human patients the role of SP110b was studied to determine its role in controlling host immunity and susceptibility to TB by modulating nuclear factor-kappaB (NF-kappaB) activity resulting in down regulation of TNF-alpha production and upregulation of NF-kappaB-induced antipoptotic gene expression suppressing IFN-gamma-mediated monocyte and/or macrophage cell death. PMID: 27858493
5. The results indicated that both the heterozygous genotype GC and homozygous genotype CC in rs3809849 in MYBBP1A had significant effects on the risk of pulmonary tuberculosis, and heterozygous genotype CT in rs9061 in SP110 also had similar effects. PMID: 25612917
6. Results show that SP110 variants were associated with increased susceptibility to both pulmonary and extra-pulmonary tuberculosis in the Vietnamese patients. Those variants may influence macrophage signaling responses and apoptosis during the infection. PMID: 25006821
7. Study suggests that a combination of SP110 and MYBBP1A gene polymorphisms may serve as a novel marker for identifying the risk of developing TB in the Chinese Han population. PMID: 23129390
8. Several SNPs in Sp110 are risk factors for susceptibility to tuberculosis in Chongqing Han People. PMID: 21033425
9. In a pooled analysis of 10,624 cases of tuberculosis, there was not a significant association between polymorphisms in the SP110 gene and disease susceptibility. [Meta-analysis] PMID: 22691368
10. Genotyped 20 SNPs located in the SP110 gene, for the first time in a South East Asian cohort from Indonesia.Our study did not reveal any statistically significant associations between SP110 SNPs and pulmonary TB. PMID: 22522001
11. a range of mutations in SP110 that cause decreased SP110 protein levels and impaired late B-cell differentiation cause veno-occlusive disease with immunodeficiency syndrome. PMID: 22621957
12. the results might indicate a role of SP110 variants in extrapulmonary tuberculosis rather than PTB. PMID: 21536091
13. This study demonstrates that genotypes and haplotypes of SP110 might be associated with susceptibility to tuberculosis in Chinese population. PMID: 21397050
14. identification of two proteins: the human remodeling and spacing factor 1 (RSF1) and the activating transcription factor 7 interacting protein (ATF7IP) that interact with human SP110 during the process of viral infections PMID: 21222611
15. data suggest that Sp110b is a transcriptional cofactor negatively regulating retinoic acid receptor alpha-mediated transcription PMID: 14559998
16. Sp110b is a component of the cellular machinery that Epstein-Barr virus utilizes to enhance lytic EBV replication PMID: 15308735
17. reports the involvement of a Sp110 nuclear body protein in a human primary immunodeficiency and high-penetrance genetic mutations in hepatic veno-occlusive disease PMID: 16648851
18. identified three polymorphisms that are associated with disease PMID: 16803959
19. Hypothesis that Sp110 variants and haplotypes might be associated with distinct phenotypes of human M tuberculosis infection is doubtful. PMID: 16816019
20. description of a minor histocompatibility antigen created by a polymorphism in the SP110 gene; the antigenic peptide comprises 2 noncontiguous SP110 peptide segments spliced together in reverse order to that in which they occur in predicted SP110 protein PMID: 16960008
21. common polymorphisms of the SP110 gene have no major effect on susceptibility to tuberculosis in the Russian population PMID: 17149599
22. Our finding suggests that genetic variations in the CYP19A1 gene are significantly associated with BMD at different skeletal sites in adult men, but not in women. PMID: 17287948
23. familial hepatic veno-occlusive disease with immunodeficiency due to a homozygous truncating mutation in exon 5; SP110 c.642delC PMID: 17510920
24. Sp110 expression is required for Anaplasma phagocytophilum infection and multiplication in human promyelocytic cells. A.phagocytophilum may modulate Sp110 mRNA levels to facilitate establishment of infection of human HL-60 cells. PMID: 17883869
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相關疾病：

Hepatic venoocclusive disease with immunodeficiency (VODI)
亞細胞定位：

Nucleus. Note=Found in the nuclear body.
組織特異性：

Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
數據庫鏈接：

HGNC: 5401

OMIM: 235550

KEGG: hsa:3431

STRING: 9606.ENSP00000258381

UniGene: Hs.145150

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