SOSTDC1 Antibody

中文名稱：

SOSTDC1兔多克隆抗體
貨號：

CSB-PA022416EA01HU
規格：

￥440
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SOSTDC1 Polyclonal antibody
Uniprot No.：

Q6X4U4
基因名：

SOSTDC1
別名：

CDA019 antibody; DKFZp564D206 antibody; Ectodermal BMP inhibitor antibody; Ectodin antibody; sclerostin domain containing 1 antibody; Sclerostin domain containing protein 1 antibody; Sclerostin domain-containing protein 1 antibody; SOSD1_HUMAN antibody; Sostdc1 antibody; USAG-1 antibody; USAG1 antibody; Uterine sensitization associated gene 1 protein antibody; Uterine sensitization-associated gene 1 protein antibody; Wise antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sclerostin domain-containing protein 1 protein (24-206AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SOSTDC1 Antibody (CSB-PA022416EA01HU)，的標記方式是Non-conjugated。對于SOSTDC1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA022416EB01HU	SOSTDC1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022416EC01HU	SOSTDC1 Antibody, FITC conjugated
Biotin	CSB-PA022416ED01HU	SOSTDC1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in the onset of endometrial receptivity for implantation/sensitization for the decidual cell reaction Enhances Wnt signaling and inhibits TGF-beta signaling. Directly antagonizes activity of BMP2, BMP4, BMP6 and BMP7 in a dose-dependent manner.
基因功能參考文獻：
1. findings provide insight into the role of SOSTDC1 as a novel functional tumor suppressor in follicular thyroid cancer through modulating the activities of PI3K/Akt and MAPK/Erk signaling pathways. PMID: 28551845
2. Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2. PMID: 26378658
3. Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. PMID: 25338303
4. Epigenetic silencing of SOSTDC1 through methylation is increased in prostate cancer and is associated with accelerated disease progression in patients with prostate cancer PMID: 25858146
5. Unliganded VDR upregulates the expression of hairless, the gene product of which acts as a downstream comodulator to feedback-repress DKKL1 and SOSTDC1. PMID: 24190897
6. DNA methylation is involved in the down-regulation of SOSTDC1 expression in gastric cancer. PMID: 23830730
7. SOSTDC1 is expressed in normal breast tissue and this expression is reduced in breast cancer. PMID: 21113658
8. Results indicate for the first time that the genetic polymorphisms in SOSTDC1 have an effect on attainment and maintenance of peak bone mass in Chinese women. PMID: 21221677
9. genetic aberrations near SOSTDC1 are not uncommon in renal cancer, and occur in adult as well as pediatric renal tumors. PMID: 21080955
10. Data suggest that ectodin is a novel bone morphogenetic protein (BMP) inhibitor which integrates BMP signaling with the SHH and FGF signal pathways PMID: 14623234
11. USAG1 is expressed in the kidney and functions as a bone morphogenetic protein antagonist. PMID: 15020244
12. This screen identified a bone morphogenetic protein (BMP) antagonist, SOSTDC1 (sclerostin domain-containing-1) as down-regulated in kidney tumors. PMID: 18032587
13. Loss of SOSTDC1 gene is associated with Wilms tumor. PMID: 19760604
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亞細胞定位：

Secreted.
蛋白家族：

Sclerostin family
組織特異性：

Highly expressed in kidney and weakly in lung.
數據庫鏈接：

HGNC: 21748

OMIM: 609675

KEGG: hsa:25928

STRING: 9606.ENSP00000304930

UniGene: Hs.648106

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