SOS2 Antibody

中文名稱：

SOS2兔多克隆抗體
貨號：

CSB-PA22327A0Rb
規格：

￥440
圖片：
Western Blot
Positive WB detected in: A549 whole cell lysate, SH-SY5Y whole cell lysate, HL60 whole cell lysate, K562 whole cell lysate, PC-3 whole cell lysate, Hela whole cell lysate
All lanes: SOS2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 153, 150 kDa
Observed band size: 153 kDa

IHC image of CSB-PA22327A0Rb diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA22327A0Rb diluted at 1:100 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of A549 cells with CSB-PA22327A0Rb at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SOS2 Polyclonal antibody
Uniprot No.：

Q07890
基因名：

SOS2
別名：

FLJ25596 antibody; Guanine nucleotide exchange factor antibody; Guanine nucleotide releasing factor antibody; Son of sevenless (Drosophilia) homolog 2 antibody; Son of sevenless homolog 2 (Drosophila) antibody; Son of sevenless homolog 2 antibody; SOS 2 antibody; SOS-2 antibody; Sos2 antibody; SOS2_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Son of sevenless homolog 2 protein (187-404AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SOS2 Antibody (CSB-PA22327A0Rb)，的標記方式是Non-conjugated。對于SOS2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA22327B0Rb	SOS2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA22327C0Rb	SOS2 Antibody, FITC conjugated
Biotin	CSB-PA22327D0Rb	SOS2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Promotes the exchange of Ras-bound GDP by GTP.
基因功能參考文獻：
1. Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome PMID: 26173643
2. We identified two novel genes, SOS2 and LZTR1, associated with Noonan syndrome, thereby expanding the molecular spectrum of RASopathies. PMID: 25795793
3. multicenter pharmacogenetic study in children (ages 6-11): Data suggest that SNP in SOS2 (rs13379306) in children with growth hormone deficiency is associated with drug resistance to hormone replacement therapy with recombinant human growth hormone. PMID: 23761422
4. intracellular Francisella tularensis novicida triggers temporal and early activation of Ras through the SOS2/GrB2/PKCalpha/PKCbetaI quaternary complex; Ras signalling by intracellular F. tularensis is essential for intracellular proliferation in the cytosol PMID: 20618341
5. Significant association of single nucleotide polymorphism within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease, was confirmed. PMID: 17440948
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相關疾病：

Noonan syndrome 9 (NS9)
數據庫鏈接：

HGNC: 11188

OMIM: 601247

KEGG: hsa:6655

STRING: 9606.ENSP00000216373

UniGene: Hs.291533

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