SORCS1 Antibody

中文名稱：

SORCS1兔多克隆抗體
貨號：

CSB-PA848843LA01HU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in: K562 whole cell lysate
All lanes: SORCS1 antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 130, 134, 132 kDa
Observed band size: 130 kDa

Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA848843LA01HU at dilution of 1:100

Immunofluorescence staining of MCF-7 cells with CSB-PA848843LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SORCS1 Polyclonal antibody
Uniprot No.：

Q8WY21
基因名：

SORCS1
別名：

SORCS1 antibody; SORCS antibody; VPS10 domain-containing receptor SorCS1 antibody; hSorCS antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human VPS10 domain-containing receptor SorCS1 protein (34-175AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁面中的產(chǎn)品，SORCS1 Antibody (CSB-PA848843LA01HU)，的標(biāo)記方式是Non-conjugated。對于SORCS1 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA848843LB01HU	SORCS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA848843LC01HU	SORCS1 Antibody, FITC conjugated
Biotin	CSB-PA848843LD01HU	SORCS1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

基因功能參考文獻(xiàn)：
1. We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin secretion in obese women with polycystic ovary syndrome. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels and increased glucose stimulated insulin secretion PMID: 27052493
2. Data identified associations between single nucleotide polymorphisms in SORCS1 and renal function in large cohorts of European and African ancestry. PMID: 23780848
3. The propeptide region of sorCS1 contains two separate sites for binding to sortilin. One of these sites is removed from human sorCS1 during processing. PMID: 24128306
4. Genetic variation of the rs10884402 and rs950809 in intron 1 of SORCS1 is associated with late onset Alzheimer disease in the Chinese Han population. PMID: 23700427
5. The genetic link between AD[Alzheimer's disease]and SORCS1 gene variations are influenced by ethnic background, sex and whether an individual has type 2 diabetes mellitus PMID: 23279143
6. [review] Emerging data from a rapidly growing area of research implicates the Vps10 family of receptors and the retromer in physiological intracellular trafficking by neurotrophins and pathogenesis of neurodegeneration. PMID: 23055476
7. Our data suggested that SORCS1 was in interaction with APOE in the development of late-onset Alzheimer's disease in a Northern Han Chinese population PMID: 22353753
8. suggest that genetic variation in SORCS1 is associated with memory performance PMID: 22046233
9. Dysfunction of SorCS1 may contribute to both the amyloid precursor protein/amyloidbeta disturbance underlying Alzheimer disease and the insulin/glucose disturbance underlying diabetes mellitus. PMID: 20881129
10. SNP which is nearest to SORCS1 is highly significantly associated with glycemic control in individuals with type 1 diabetes PMID: 19875614
11. human sorCS1 has three isoforms, sorCS1a-c, with completely different cytoplasmic tails and differential expression in tissues PMID: 12482870
12. Different motifs regulate trafficking of SorCS1 isoforms. PMID: 18315530
13. SORCS1 SNPs show genotypic association with Alzheimer disease. PMID: 19241460
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亞細(xì)胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

VPS10-related sortilin family, SORCS subfamily
組織特異性：

Detected in fetal and infant brain and in fetal retina.
數(shù)據(jù)庫鏈接：

HGNC: 16697

OMIM: 606283

KEGG: hsa:114815

STRING: 9606.ENSP00000345964

UniGene: Hs.591915

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