SORBS3 Antibody

中文名稱：

SORBS3兔多克隆抗體
貨號：

CSB-PA022406LA01HU
規格：

￥440
圖片：
Western blot
All lanes: SORBS3 antibody at 8µg/ml + HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 76, 37 kDa
Observed band size: 76 kDa

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA022406LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA022406LA01HU at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SORBS3 Polyclonal antibody
Uniprot No.：

O60504
基因名：

SORBS3
別名：

SORBS3 antibody; SCAM1 antibody; Vinexin antibody; SH3-containing adapter molecule 1 antibody; SCAM-1 antibody; Sorbin and SH3 domain-containing protein 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Vinexin protein (1-329AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SORBS3 Antibody (CSB-PA022406LA01HU)，的標記方式是Non-conjugated。對于SORBS3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA022406LB01HU	SORBS3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA022406LC01HU	SORBS3 Antibody, FITC conjugated
Biotin	CSB-PA022406LD01HU	SORBS3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
基因功能參考文獻：
1. Vinexin beta deficiency attenuates atherogenesis primarily by suppressing vascular inflammation and inactivating Akt-nuclear factor kappaB signaling. Our data suggest that vinexin beta could be a therapeutic target for the treatment of atherosclerosis. PMID: 28209562
2. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
3. Study identified possible epigenetic influence on differential gene expression in SORBS3 under obese conditions. PMID: 27437034
4. Our findings revealed that Vinexin-beta acts as a novel modulator of ischaemic injury PMID: 25824575
5. Taken together, the findings suggest that vinexin beta modulates NS5A phosphorylation via its interaction with NS5A, thereby regulating hepatitis C virus replication, implicating vinexin beta in the viral life cycle. PMID: 25972535
6. Vinexin knockdown using siRNA delayed migration of both HaCaT human keratinocytes and A431 epidermoid carcinoma cells in scratch assay but did not affect cell proliferation. PMID: 20361963
7. regulates cytoskeletal organization and signal transduction--review PMID: 12510380
8. vinexin is a novel substrate of ERK2 and may play roles in ERK-dependent cell regulation PMID: 15184391
9. phosphorylation of the AF-1 domain controls RARgamma-mediated transcription through triggering the dissociation of vinexin beta PMID: 15734736
10. These results suggest that vinexin beta plays a role in maintaining the phosphorylation of EGFR on the plasma membrane through the regulation of c-Cbl. PMID: 16923119
11. Vinexin is enriched at the leading edge of migrating cells, lamellipodia and and focal adhesions in well-spread cells. PMID: 17486060
12. Rhotekin forms a complex with vinexin and may play a role at focal adhesions. PMID: 19294487
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亞細胞定位：

[Isoform Alpha]: Cell junction. Cytoplasm, cytoskeleton.; [Isoform Beta]: Cell junction. Nucleus. Cytoplasm, cytoskeleton.
組織特異性：

Both isoforms are expressed in different tissues like heart, placenta, brain, skeletal muscle and pancreas. Isoform beta is especially found in liver.
數據庫鏈接：

HGNC: 30907

OMIM: 610795

KEGG: hsa:10174

STRING: 9606.ENSP00000240123

UniGene: Hs.528572

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