SNRPN Antibody

說明書

中文名稱：

SNRPN兔多克隆抗體
貨號：

CSB-PA022343GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P63162
基因名：

SNRPN
別名：

HCERN3 antibody; PWCR antibody; RSMN_HUMAN antibody; RT LI antibody; RTLI antibody; SM D antibody; Sm N antibody; Sm protein D antibody; Sm protein N antibody; Sm-D antibody; Sm-N antibody; Small nuclear ribonucleoprotein associated protein N antibody; Small nuclear ribonucleoprotein polypeptide N antibody; Small nuclear ribonucleoprotein-associated protein N antibody; SMD antibody; SmN antibody; SNRNP N antibody; snRNP-N antibody; SNRNPN antibody; SNRPN antibody; SNURF SNRPN antibody; Tissue specific splicing protein antibody; Tissue-specific-splicing protein antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SNRPN
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in tissue-specific alternative RNA processing events.
基因功能參考文獻：
1. The first study reporting an association between variability in the SNRPN gene and the risk of being obese. PMID: 28387446
2. we have confirmed that SNRPN methylation increases with age, which raises further questions regarding the role of SNRPN expression during the aging process. PMID: 26535694
3. the cases with partial loss of methylation in KCNQ1OT1 and SNRPN present clinical features different to those associated with the corresponding imprinting syndromes PMID: 26106604
4. Knockdown of SNRPN was demonstrated to significantly inhibit medulloblastoma cell growth and induce G2/M phase arrest in vitro. PMID: 25571951
5. Data indicate that Sm nuclear antigen SmD-specific clonotypic IgGs showed extensive V- region hypermutation. PMID: 25577500
6. indicate that SmN expression reduces the level of mature U2 snRNP, leading to alternative splicing PMID: 25238490
7. The methylation patterns of the promoters of MTHFR and SNRPN are associated with changes in sperm motility and morphology, which could lead to male infertility. PMID: 24365028
8. Human amniotic fluid mesenchymal stem cells contain a unique epigenetic signature during in vitro cell culture. H19 and KCNQ1OT1 possessed a substantial degree of hypermethylation status, and variable DNA methylation patterns of SNRPN was observed. PMID: 23040914
9. In the skeletal muscle of neonate pigs, both NECD and SNRPN were maternally imprinted, while UBE3A was not imprinted. PMID: 22711311
10. genetic association studies using 1,000 white subjects from Midwestern United States: Three copy number variations (CNV) in PWCR are associated with body fat mass, with a higher copy number (CN) associated with an increase of in body fat mass. PMID: 21233802
11. Differences between genetic subtypes were also statistically significant in Prader Willi syndrome PMID: 21227640
12. Variable methylation of the imprinted gene, SNRPN, supports a relationship between intracranial germ cell tumours and neural stem cells. PMID: 20582452
13. SNRPN gene is imprinted, with monoallelic expression from the paternal allele in fetal brain and heart, and in adult brain. PMID: 7512861
14. MEG3 and SNRPN genes are abnormally methylated in AML and MDS patients, and methylation of MEG3, but not SNRPN, confers worse overall prognosis. PMID: 19595458
15. Methylation imprints of the imprint control region of the SPRPN-gene were studied in gametes and preimplantation embryos. ametes PMID: 14500540
16. SMB and CD2BP2-GYF interact in the spliceosome PMID: 15105431
17. Identification of cis- and trans-acting regulatory elements within the endogenous SNRPN 5' region. PMID: 16116039
18. a possibly inactivating mutation in the SNRPN minimal promoter region was identified in Prader-Willi syndrome PMID: 17262171
19. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 18361419
20. A mouse model for Prader-Willi syndrome. Deletion of Snrpn gene and putative imprinting-centre is associated with absent expression of the imprinted genes Zfp127, Ndn and Ipw, and phenotypes similar to those found in Prader-Willi infants. PMID: 9590284
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亞細胞定位：

Nucleus.
蛋白家族：

SnRNP SmB/SmN family
組織特異性：

Expressed in brain and lymphoblasts.
數據庫鏈接：

HGNC: 11164

OMIM: 182279

KEGG: hsa:6638

STRING: 9606.ENSP00000306223

UniGene: Hs.564847

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