SMOX Antibody

說明書

中文名稱：

SMOX兔多克隆抗體
貨號：

CSB-PA021844GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NWM0
基因名：

SMOX
別名：

SMOX antibody; C20orf16 antibody; SMO antibody; UNQ3039/PRO9854 antibody; Spermine oxidase antibody; EC 1.5.3.16 antibody; Polyamine oxidase 1 antibody; PAO-1 antibody; PAOh1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SMOX
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
基因功能參考文獻：
1. Data suggest that intermolecular disulfide bond links spermine oxidase (SMOX) molecules to form the homodimer and plays a critical role in the stabilization of the overall three-dimensional SMOX structure. PMID: 29138259
2. These results indicate a protective role for miR-124 through the inhibition of SMOX-mediated DNA damage in the etiology of H. pylori-associated gastric cancer. PMID: 27041578
3. effect of Tat on Nrf2 activation in human neuroblastoma cells and the role of NMDA receptor and spermine oxidase on Tat-induced nuclear factor erythroid 2-related factor 2 (Nrf2) activation PMID: 26895301
4. During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydrogen peroxide from the catabolism of the polyamine spermine, and increases gastric cancer risk. PMID: 25174398
5. study postulates a mechanism for SAT1 and SMOX down-regulation by post-transcriptional activity of miRNAs. PMID: 24025154
6. Tat was found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase (SMO) PMID: 23665428
7. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. PMID: 21839041
8. each gene was associated with at least one main outcome: anxiety (SAT1, SMS), mood disorders (SAT1, SMOX), and suicide attempts (SAT1, OATL1). PMID: 21152090
9. Spermine oxidase (SMO) has a role in response to BENSpm and CPENSpm in breast tumor cells PMID: 20946629
10. Increased expression of spermine oxidase is associated with ulcerative colitis. PMID: 20127992
11. the genetic and epigenetic factors examined in this study show little influence on the expression level of SMOX in suicide completers. PMID: 20059804
12. Knockdown studies suggest that induction of SSAT and SMO is correlated with the antiproliferative effects of BENSpm with 5-FU or paclitaxel in MDA-MB-231 cells. PMID: 19727732
13. Fully protonated forms of the inhibitors and the unprotonated form of an amino acid residue with a pK(a) of approximately 7.4 in the active site are preferred for binding. PMID: 20000632
14. There are at least four isoenzymes of human PAO, each with different biochemical characteristics and roles in polyamine catabolism PMID: 12398765
15. The results of these studies are consistent with the hypothesis that polyamine oxidase 1 (PAOh1/SMO) represents a new addition to the polyamine metabolic pathway. PMID: 12727196
16. SSAT and SMO(PAOh1) activities are the major mediators of the cellular response of breast tumor cells to polyamines while PAO plays little or no role in this response PMID: 16207710
17. Tissues from patients with prostate cancer and prostatic intraepithelial neoplasia exhibit increased spermine oxidase expression. PMID: 18302221
18. analysis of nuclear localization of human spermine oxidase isoforms PMID: 18422650
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亞細胞定位：

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.
蛋白家族：

Flavin monoamine oxidase family
組織特異性：

Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line.
數據庫鏈接：

HGNC: 15862

OMIM: 615854

KEGG: hsa:54498

STRING: 9606.ENSP00000307252

UniGene: Hs.433337

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