SMC4 Antibody

中文名稱：

SMC4兔多克隆抗體
貨號：

CSB-PA885725YA01HU
規格：

￥440
圖片：
Immunohistochemistry analysis of human colon cancer using CSB-PA885725YA01HU at dilution of 1:100

Immunocytochemistry analysis of human kidney tissue using CSB-PA885725YA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA885725YA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SMC4 Polyclonal antibody
Uniprot No.：

Q9NTJ3
基因名：

SMC4
別名：

CAP C antibody; CAPC antibody; Chromosome associated polypeptide C antibody; Chromosome-associated polypeptide C antibody; hCAP C antibody; hCAP-C antibody; SMC 4 antibody; SMC protein 4 antibody; SMC-4 antibody; SMC4 antibody; SMC4_HUMAN antibody; SMC4L1 antibody; Structural maintenance of chromosomes 4 antibody; Structural maintenance of chromosomes 4 like 1 antibody; Structural maintenance of chromosomes protein 4 antibody; XCAP C homolog antibody; XCAP-C homolog antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Structural maintenance of chromosomes protein 4 protein (406-501AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SMC4 Antibody (CSB-PA885725YA01HU)，的標記方式是Non-conjugated。對于SMC4 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA885725YB01HU	SMC4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885725YC01HU	SMC4 Antibody, FITC conjugated
Biotin	CSB-PA885725YD01HU	SMC4 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
基因功能參考文獻：
1. analysis of functional differences of SMC2 and SMC4 hinge domain between condensins and cohesin in DNA recognition PMID: 26491021
2. Results indicate that miR-124-5p may target the tumorigenesis gene, SMC4, which suggests that expression levels of miR-124-5p in plasma and FFPE samples. PMID: 25081869
3. Knockdown of SMC-4 expression significantly suppressed the proliferation. PMID: 25422241
4. SMC4 expression was significantly associated with tumor size, de-differentiation, advanced stages and vascular invasion of the primary liver cancers. PMID: 22842912
5. mutation analysis of hCAP-C & hCAP-E in leukemia-lymphoma cell lines including 8 pyothorax-associated lymphoma (PAL); 3 of 8 PAL cell lines have hCAP-C or hCAP-E heterozygous mutations, indicating condensin mutations are relatively frequent in PAL PMID: 17488335
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亞細胞定位：

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
蛋白家族：

SMC family, SMC4 subfamily
組織特異性：

Widely expressed. Higher expression in testis, colon, thymus.
數據庫鏈接：

HGNC: 14013

OMIM: 605575

KEGG: hsa:10051

STRING: 9606.ENSP00000341382

UniGene: Hs.58992

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