SMARCD3 Antibody, FITC conjugated
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中文名稱：SMARCD3兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA754358LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) SMARCD3 Polyclonal antibody
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Uniprot No.：
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基因名：SMARCD3
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別名：60 kDa BRG 1/Brm associated factor subunit C antibody; 60 kDa BRG-1/Brm-associated factor subunit C antibody; BAF60C antibody; BRG1 associated factor 60C antibody; BRG1-associated factor 60C antibody; Chromatin remodeling complex BAF60C subunit antibody; CRACD3 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 60C antibody; MGC111010 antibody; Rsc6p antibody; Smarcd3 antibody; SMRD3_HUMAN antibody; SWI/SNF complex 60 kDa subunit C antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 3 antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3, isoform 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 antibody; Swp73 like protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 protein (2-101AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Stimulates nuclear receptor mediated transcription. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
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基因功能參考文獻：
- Data show that the combination of GATA binding protein 4 (Gata4), T-box transcription factor 5 (Tbx5) and BRG1-associated factor 60C protein (Baf60c) is sufficient for inducing adipose tissue-derived mesenchymal stem cells (ADMSCs) to form cardiomyocytes. PMID: 26071180
- Inhibition of Wnt5a by either RNAi knockdown or blocking antibody reversed Smarcd3 -induced epithelial-mesenchymal transition. Thus, Smarcd3 epigenetically regulates epithelial-mesenchymal transition by activating WNT signaling pathways. PMID: 23716599
- Deptor is induced by the Baf60c-Six4 transcriptional complex and mediates activation of Akt and glycolytic metabolism by Baf60c in a cell-autonomous manner PMID: 23563706
- BAF60c promotes lipogenesis in vivo and increases triglyceride levels, demonstrating its role in metabolic adaption to activate the lipogenic program in response to feeding and insulin. PMID: 23219531
- Data show a combination of only five genes (-BCL6, T (BRACHYURY), c-MYC, MITF and BAF60C (SMARCD3) rapidly and efficiently convert postnatal chorion and decidual cells into chondrocytes. PMID: 22833560
- BAF60c phosphorylation on a conserved threonine is the signal that promotes incorporation of MyoD-BAF60c into a Brg1-based SWI/SNF complex, which remodels the chromatin & activates transcription of MyoD-target genes. PMID: 22068056
- GTNB directs cardiogenesis from human embryonic stem cells and induces correct cardiac development. PMID: 21694703
- BAF60c represents a new coregulator that constitutes an important anchoring point by which the SWI/SNF complex is recruited to nuclear receptors and other transcription factors PMID: 14701856
- Tat-mediated activation of the HIV promoter requires the SWI/SNF complex in synergy with the coactivator p300. PMID: 16687403
- Baf60c is re-expressed in the Muller glial cells that re-enter the cell cycle after neurotoxic damage PMID: 18816825
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亞細胞定位：Nucleus.
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蛋白家族：SMARCD family
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組織特異性：Isoform 2 and isoform 1 are expressed in brain, heart, kidney, placenta, prostate, salivary gland, spleen, testis, thyroid, trachea and uterus. Isoform 1 is also expressed in skeletal muscle and adipose tissue.
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