SLC8B1 Antibody
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中文名稱：SLC8B1兔多克隆抗體
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貨號：CSB-PA404751
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA404751(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA404751(SLC8B1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200) -
Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-2: Human placenta tissue, Human normal kidney tissue,Primary antibody: CSB-PA404751(SLC8B1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
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其他：
產品詳情
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Uniprot No.：
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基因名：SLC8B1
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別名：FLJ22233 antibody; Na(+)/K(+)/Ca(2+) exchange protein 6 antibody; Na(+)/K(+)/Ca(2+)-exchange protein 6 antibody; NCKX6 antibody; NCKX6_HUMAN antibody; NCLX antibody; Slc24a6 antibody; Sodium/potassium/calcium exchanger antibody; Sodium/potassium/calcium exchanger 6 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 6 antibody; Solute carrier family 24 member 6 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide of Human SLC8B1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:1000-1:2000 WB 1:200-1:1000 IHC 1:25-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion. Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes. Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses. Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity. Involved in B-lymphocyte chemotaxis. Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+).
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基因功能參考文獻：
- It has been shown that the propagation of the TRPV1-induced cytosolic calcium and sodium fluxes into mitochondria is dependent on coordinated activity of NCLX and MCU. PMID: 27627464
- Store-operated Ca(2+) entry activates a mitochondrial redox transient which is dependent on NCLX and is required for preventing Orai1 inactivation through oxidation of a critical cysteine (Cys195) in the third transmembrane helix of Orai1. PMID: 28219928
- NCLX, but not LETM1, mediates Ca(2+) extrusion from mitochondria. By controlling the duration of matrix Ca(2+) elevations, NCLX contributes to the regulation of NAD(P)H production and to the conversion of Ca(2+) signals into redox changes. PMID: 24898248
- NCKX6 is a novel member of the Na+/Ca2+ exchanger superfamily PMID: 14625281
- NCLX catalyzes active Li(+)/Ca(2+) exchange. PMID: 15060069
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亞細胞定位：Mitochondrion inner membrane; Multi-pass membrane protein.
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蛋白家族：Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
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組織特異性：Present in pancreatic beta-cells (at protein level).
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數據庫鏈接：
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