SLC6A6 Antibody

說明書

中文名稱：

SLC6A6兔多克隆抗體
貨號：

CSB-PA546856
規格：

￥2024
圖片：
Western blot analysis of extracts from COLO205 cells, using SC6A6 antibody.

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SC6A6 antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC6A6 Polyclonal antibody
Uniprot No.：

P31641
基因名：

SLC6A6
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from internal of Human SC6A6.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000
IHC	1:50-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sodium-dependent taurine and beta-alanine transporter. Chloride ions are necessary for optimal uptake.
基因功能參考文獻：
1. TauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine. PMID: 26955642
2. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in renal epithelial cells; CDNP1 may have a role in diabetic neuropathy PMID: 26206726
3. This is the first study to present information on the transcriptional regulation of taurine transporter gene and the localization of the taurine transporter protein in chondrocytic cells. PMID: 25501278
4. Neurotransmitter transporters including SLC6A6 and SLC6A13 mediate the uptake of 5-aminolevulinic acid (ALA) and can play roles in the enhancement of ALA-induced accumulation of protoporphyrin in cancerous cells. PMID: 24842606
5. Immunocytochemistry and flow cytometry analyses revealed that these mAbs recognized the native form of the extracellular domain of SLC6A6 on the cell surface. PMID: 24866236
6. Taurine transporter is a novel pathological marker for stressed motor neurons in amyotrophic lateral sclerosis. PMID: 23180277
7. Taurine transporter deficiency results in aberrant trophoblast turnover and fetal growth restriction. PMID: 23519128
8. Syncytiotrophoblast TauT activity is reduced in maternal obesity and pre-eclampsia compared to normal pregnancy. PMID: 23392873
9. Knockdown of TauT impairs kidney development, possibly through regulation of cell cycle-related genes. PMID: 23392892
10. TauT gene is overexpressed in peripheral blood mononuclear cells of type 2 diabetic patients. PMID: 21739148
11. TNF-alpha-treated cells showed a higher mRNA level of the TAUT (taurine transporter) than did the control cells. PMID: 12062416
12. TauT is involved with p53 in renal development and apoptosis. PMID: 12163498
13. regulation by WT1 PMID: 12681485
14. nitric oxide plays an important role in downregulating microvillous plasma membrane taurine transporter activity in intrauterine growth restriction PMID: 15166008
15. The increased expression level of TAUT mRNA by hypertonicity was repressed by the specific Ca(2+)/CaM kinase II inhibitor. PMID: 15225620
16. TAUT activity in TNF-alpha-treated Caco-2 cells suggests that up-regulation was associated with an increase in the amount of TAUT. PMID: 15630186
17. reporter assay revealed that TNF-alpha-induced TAUT transcriptional activity through the NF-kappaB consensus-like sequence in the human TAUT promoter region PMID: 15907840
18. taurine cotransporter is regulated by oxidative stress and overexpression of aldose reductase and high glucose impair this response PMID: 16356117
19. Greater system beta activity in fetal platelets compared with T lymphocytes is the result of relatively greater TAUT mRNA and protein expression. PMID: 16956961
20. Report taurine transporter activity in fetal T lymphocytes in intrauterine growth restriction and with tumor necrosis factor-alpha treatment. PMID: 18703994
21. This study demonstrates the functional coexpression of TauT along with the PAT1 transporter (SLC36A1) at the apical membrane of the intestinal epithelium. PMID: 19074966
22. critical role in protecting against cisplatin-induced nephrotoxicity, possibly by attenuating a p53-dependent pathway PMID: 19423693
23. Glucose reduced taurine transporter (TauT) mRNA and protein in a dose-dependent manner. PMID: 19602579
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A6 subfamily
組織特異性：

Expressed abundantly in placenta and skeletal muscle, at intermediate levels in heart, brain, lung, kidney and pancreas and at low levels in liver.
數據庫鏈接：

HGNC: 11052

OMIM: 186854

KEGG: hsa:6533

STRING: 9606.ENSP00000354107

UniGene: Hs.529488

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