SLC52A2 Antibody, HRP conjugated
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中文名稱：SLC52A2兔多克隆抗體, HRP偶聯
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貨號：CSB-PA881008LB01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SLC52A2 Polyclonal antibody
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Uniprot No.：
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基因名：SLC52A2
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別名：SLC52A2 antibody; GPR172A antibody; PAR1 antibody; RFT3 antibody; Solute carrier family 52 antibody; riboflavin transporter antibody; member 2 antibody; Porcine endogenous retrovirus A receptor 1 antibody; PERV-A receptor 1 antibody; Protein GPR172A antibody; Riboflavin transporter 3 antibody; hRFT3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Solute carrier family 52, riboflavin transporter, member 2 protein (217-276AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：HRP
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4-hydroxybutyrate (Probable).; (Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
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基因功能參考文獻：
- RFVT2 gene and protein expression levels were higher in DLD-1 and HT-29 compared to Caco2 cells. In tumor tissues of patients with CRC, RFVT2 gene expression levels were increased, while protein expression was reduced, with a small reduction in riboflavin amount. PMID: 29715086
- This is the second report of the genotype-phenotype correlation between this syndrome named spinocerebellar ataxia with blindness and deafness type 2 (SCABD2) and SLC52A2 gene. PMID: 29287867
- Eight mutations in SLC52a2 were associated with Brown-Vialetto-Van Laere syndrome. PMID: 29053833
- A novel SLC52A2 mutation identified in a family with spinocerebellar ataxia with blindness and deafness. PMID: 26669662
- This study showed that Auditory neuropathy in Brown-Vialetto-Van Laere syndrome due to riboflavin transporter RFVT2 deficiency and improved by riboflavin treatment. PMID: 26918385
- These results strongly implicate a potential role for SLC52A2 in riboflavin uptake by milk-producing MECs, a critical step in the transfer of riboflavin into breast milk. PMID: 26791833
- Mutations in SLC52A2 result in a recognizable phenotype distinct from Brown-Vialetto-Van-Laere syndrome. PMID: 24616084
- We demonstrate that SLC52A2 mutations cause reduced riboflavin uptake and reduced riboflavin transporter protein expression PMID: 24253200
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相關疾病：Brown-Vialetto-Van Laere syndrome 2 (BVVLS2)
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：Riboflavin transporter family
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組織特異性：Highly expressed in brain, fetal brain and salivary gland. Weakly expressed in other tissues.
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數據庫鏈接：
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