SLC4A2 Antibody

說明書

中文名稱：

SLC4A2兔多克隆抗體
貨號：

CSB-PA021667DSR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA021667DSR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA021667DSR2HU at dilution of 1:100
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC4A2 Polyclonal antibody
Uniprot No.：

P04920
基因名：

SLC4A2
別名：

AE 2 antibody; AE2 anion exchanger antibody; Anion exchange protein 2 antibody; Anion exchanger 2 antibody; B3A2_HUMAN antibody; BAND 3-LIKE PROTEIN antibody; BND3L antibody; EPB3L1 antibody; erythrocyte band 3 antibody; Erythrocyte membrane protein band 3 like 1 antibody; HKB3 antibody; MPB3L antibody; NBND3 antibody; Non-erythroid band 3-like protein antibody; Slc4a2 antibody; Solute carrier family 4 member 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Anion exchange protein 2 protein (95-245AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plasma membrane anion exchange protein of wide distribution.
基因功能參考文獻：
1. The regulation of a basolateral located, DIDS-sensitive, Cl(-)/HCO3(-) exchanger, anion exchanger 2 (AE2; SLC4A2) which is postulated to act as an acid loader, and therefore potential regulator of HCO3(-) secretion, in human airway epithelial cells. PMID: 28455748
2. To match the stimulatory effect on acid uptake, cell-to-cell coupling in NHDF-Ad and CCD-112-CoN cells was strengthened with TGFbeta1.Importantly, the activities of stromal AE2 and connexin-43 do not place an energetic burden on cancer cells, allowing resources to be diverted for other activities PMID: 27543333
3. ABA transport in human nucleated cells occurs via the anion exchanger AE2 PMID: 27015766
4. down-regulation in primary biliary cholangitis sensitizes cholangiocytes to apoptotic insults by activating soluble adenylyl cyclase PMID: 26991014
5. regulatory proteins for Cl(-)/HCO3(-) exchanger 2 activity PMID: 26716707
6. AE2 is a major pathway for basolateral Cl(-) loading during cAMP-stimulated secretion of Cl(-) and fluid by Calu-3 cells PMID: 22802585
7. A novel signal pathway involved in gastrin-stimulated AE2 expression mediated by EGR1 in gastric cancer cells. PMID: 23121767
8. miR-506 is up-regulated in primary biliary cirrhosis, binds the 3'UTR region of AE2 mRNA, and prevents protein translation, leading to diminished AE2 activity and impaired biliary secretory functions. PMID: 22383162
9. CTLA4 and SLC4A2 genetic polymorphisms are differentially associated with primary biliary cirrhosis development and progression, as well as anti-gp210 or anti-centromere antibody production, in Japanese PBC patients PMID: 21594562
10. Dysfunctions related to AE2 might have a role in the pathogenesis of primary biliary cirrhosis. PMID: 21691115
11. AE2 mediated-apoptosis of endothelial cells induced by high glucose was Caspase-3-dependent. PMID: 20180022
12. AE2 operates in parallel with NHE1 to regulate pH(i) during RVD of human cervical cancer cells. PMID: 11852051
13. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. PMID: 12225956
14. findings suggest that HNF1 may have a major role in upregulating alternative transcription of the AE2 gene in the liver, and therefore it may contribute to the biliary secretion of bicarbonate in response to certain stimuli PMID: 14575719
15. The results indicated that overexpression of AE2 may be involved in the development of human HCC. PMID: 17058451
16. SLC4A2 colocalized with carbonic anhydrase IX in gastric mucosa. PMID: 17652430
17. AE2 might be associated with gastric carcinogenesis and the achlorhydria experienced by gastric cancer patients. PMID: 18438347
18. that AE2 may play an important role in the progression of hepatocellular carcinoma cells PMID: 19224338
19. The common genetic variation of SLC4A2 does not directly affect the risk of PBC or its clinical outcome. PMID: 19491853
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亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

Anion exchanger (TC 2.A.31) family
數據庫鏈接：

HGNC: 11028

OMIM: 109280

KEGG: hsa:6522

STRING: 9606.ENSP00000405600

UniGene: Hs.647069

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