SLC34A3 Antibody, Biotin conjugated

說明書

中文名稱：

SLC34A3兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA854015LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC34A3 Polyclonal antibody
Uniprot No.：

Q8N130
基因名：

SLC34A3
別名：

HHRH antibody; Na(+) dependent phosphate cotransporter 2C antibody; Na(+) Pi cotransporter 2C antibody; Na(+)-dependent phosphate cotransporter 2C antibody; Na(+)/Pi cotransporter 2C antibody; NaPi 2c antibody; NaPi-2c antibody; NPT2C antibody; NPT2C_HUMAN antibody; NPTIIC antibody; SLC34A3 antibody; Sodium dependent phosphate transport protein 2C antibody; Sodium inorganic phosphate cotransporter IIC antibody; Sodium phosphate cotransporter 2C antibody; Sodium phosphate transport protein 2C antibody; Sodium-dependent phosphate transport protein 2C antibody; Sodium-phosphate transport protein 2C antibody; Sodium/inorganic phosphate cotransporter IIC antibody; Sodium/inorganic phosphate cotransporter; type IIC antibody; Sodium/phosphate cotransporter 2C antibody; solute carrier family 34 (sodium phosphate) member 3 antibody; solute carrier family 34 (sodium/phosphate contransporter); member 3 antibody; solute carrier family 34 (type II sodium/phosphate contransporter); member 3 antibody; Solute carrier family 34 member 3 antibody; type IIc Na+ Pi cotransporter antibody; Type IIc Na+/Pi cotransporter antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sodium-dependent phosphate transport protein 2C protein (1-76AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.
基因功能參考文獻：
1. genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3 PMID: 29505567
2. This is the report of a patient with compound heterozygous mutations of SLC34A3 and normal skeletal features. Biallelic mutations in SLC34A3 can thus be associated with hypercalciuria not accompanied by rickets. PMID: 24924704
3. Individuals with mutations affecting both SLC34A3 alleles had a significantly increased risk of kidney stone formation or medullary nephrocalcinosis, namely 46% compared with 6% observed in healthy family members carrying only the wild-type allele. PMID: 24700880
4. this study reports the first cases of hereditary hypophosphatemic rickets with hypercalciuria in Africa and describes a novel causal mutation within the SLC34A3 gene PMID: 23246670
5. A man with hereditary hypophosphataemic rickets with hypercalciuria & his 3 heterozygous children had a mutation in intron 5 of gene SLC34A3 (NM_080877.2:c[ 448 +5G>A] + [ 448 +5G>A]). PMID: 22806288
6. Data show 101-bp deletion in intron 9 of the SLC34A3 gene. PMID: 22672866
7. SLC34A3 mutations (exons and introns) were searched in two previously not reported hereditary hypophosphatemic rickets with hypercalciuria kindreds, which resulted in the identification of three novel mutations. PMID: 22387237
8. these data suggest that mutations in SLC34A3 in hereditary hypophosphatemic rickets with hypercalciuria result in defective processing and stability PMID: 22159077
9. Functionally important sites in the predicted first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter (NaPi-IIa) were identified by cysteine scanning mutagenesis (Ehnes et al., 2004). PMID: 15504899
10. NaP(i)-IIc has a key role in the regulation of phosphate homeostasis. PMID: 16358214
11. Loss of function of the SLC34A3 protein presumably results in a primary renal tubular defect and is compatible with the hereditary hypophosphatemic rickets with hypercalciuria phenotype. PMID: 16358215
12. Therefore, understanding the mechanisms that control the apical expression of NaPi-IIa and NaPi-IIc as well as their functional properties is critical to understanding how an organism achieves P i homeostasis. PMID: 16955105
13. Hereditary hypophosphatemic rickets with hypercalciuria were speculated to be associated with the abnormal functions of phosphate transporter gene type IIc. PMID: 17968493
14. A novel missense mutation in SLC34A3 causes hereditary hypophosphatemic rickets with hypercalciuria in humans. PMID: 18480181
15. Novel mutation in the SLC34A3 gene in a patient with an unusual presentation of hereditary hypophosphatemic rickets with hypercalciuria. PMID: 19820004
顯示更多

收起更多
相關疾病：

Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
亞細胞定位：

Membrane; Multi-pass membrane protein.
蛋白家族：

SLC34A transporter family
數據庫鏈接：

HGNC: 20305

OMIM: 241530

KEGG: hsa:142680

STRING: 9606.ENSP00000355353

UniGene: Hs.432442

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human