SLC33A1 Antibody

說明書

中文名稱：

SLC33A1兔多克隆抗體
貨號：

CSB-PA291254
規(guī)格：

￥1100
圖片：
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA291254(SLC33A1 Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
其他：

產(chǎn)品詳情

Uniprot No.：

O00400
基因名：

SLC33A1
別名：

ACATN antibody; ACATN_HUMAN antibody; Acetyl CoA transporter antibody; Acetyl Coenzyme A transporter antibody; Acetyl coenzyme A transporter 1 antibody; Acetyl-CoA transporter 1 antibody; Acetyl-coenzyme A transporter 1 antibody; AT 1 antibody; AT-1 antibody; AT1 antibody; Human Angiotensin II Type 1 Receptor antibody; Slc33a1 antibody; Solute carrier family 33 (acetyl CoA transporter) member 1 antibody; Solute carrier family 33 member 1 antibody; spastic paraplegia 42 (autosomal dominant) antibody; SPG42 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human SLC33A1
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
WB	1:1000-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling.
基因功能參考文獻(xiàn)：
1. results indicate that increased expression of AT-1 can cause an autistic-like phenotype by affecting key neuronal metabolic pathways. PMID: 27242167
2. SLC33A1 can negatively regulate BMP signaling. PMID: 25402622
3. Homozygosity mapping displayed a region of commonality among three families at chromosome 3q25. Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1. PMID: 22243965
4. translocates acetyl-CoA into the ER lumen and is essential for cell viability PMID: 20826464
5. A missense mutation in SLC33A1 causes autosomal-dominant spastic paraplegia. PMID: 19061983
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相關(guān)疾病：

Spastic paraplegia 42, autosomal dominant (SPG42); Congenital cataracts, hearing loss, and neurodegeneration (CCHLND)
亞細(xì)胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein.
蛋白家族：

SLC33A transporter family
組織特異性：

Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
數(shù)據(jù)庫鏈接：

HGNC: 95

OMIM: 603690

KEGG: hsa:9197

STRING: 9606.ENSP00000352456

UniGene: Hs.478031

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