SLC30A6 Antibody, FITC conjugated
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中文名稱：SLC30A6兔多克隆抗體, FITC偶聯
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貨號：CSB-PA744010LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SLC30A6 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：SLC30A6; ZNT6; Zinc transporter 6; ZnT-6; Solute carrier family 30 member 6
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Zinc transporter 6 protein (246-461AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.
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基因功能參考文獻：
- There was a significant increase in protein levels of ZnT6 in the prefrontal cortex in Major depression disorder, relative to control subjects. PMID: 27661418
- A genetic variant within SLC30A6 has a protective role in the severity of Rheumatoid Arthritis. PMID: 27758124
- results of this study suggested that ZnT6 protein levels are decreased in the spinal cords of sporadic ALS patients. PMID: 25284286
- The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. PMID: 22349685
- our results suggest that alterations in Zn transport proteins ZnT-1, ZnT-4 and ZnT-6 may contribute to the pathology observed in preclinical Alzheimer's disease subjects before onset of clinical symptoms PMID: 19371353
- Our results show that Zn transporter-4 and Zn transporter-6 are significantly (P<0.05) increased in hippocampus/parahippocampal gyrus of early Alzheimer's disease and Alzheimer's disease subjects. PMID: 16580781
- hZnT-6 is up-regulated in response to cellular zinc depletion in Raji & THP-1 cells. PMID: 17971500
- Data show that ZNT6 is extensively present in the Abeta-positive plaques in the cortex of human AD brains. PMID: 18639746
- The cytosolic C-terminal tail of ZnT5 is important for its interaction with ZnT6 as a heterodimer. PMID: 19759014
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亞細胞定位：Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein.
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蛋白家族：Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
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組織特異性：Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve,
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