SLC27A1 Antibody

說明書

中文名稱：

SLC27A1兔多克隆抗體
貨號：

CSB-PA138175
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA138175(SLC27A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA138175(SLC27A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q6PCB7
基因名：

SLC27A1
別名：

SLC27A1 antibody; ACSVL5 antibody; FATP1Long-chain fatty acid transport protein 1 antibody; FATP-1 antibody; Fatty acid transport protein 1 antibody; EC 6.2.1.- antibody; Solute carrier family 27 member 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human SLC27A1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediates the ATP-dependent import of long-chain fatty acids (LCFA) into the cell by mediating their translocation at the plasma membrane. Has also an acyl-CoA ligase activity for long-chain and very-long-chain fatty acids. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Probably involved in fatty acid transport across the blood barrier.
基因功能參考文獻：
1. Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression PMID: 26867681
2. Several proteins that are expressed in the epidermis have been proposed to facilitate the uptake of long-chain fatty acids (LCFA) in mammalian cells, CD36, fatty acid binding protein, and FATP. [review] PMID: 24120574
3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20965718
4. Observational study of gene-disease association. (HuGE Navigator) PMID: 19913121
5. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20628086
6. FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase PMID: 20356843
7. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20416077
8. exogenously supplied fatty acids are preferentially channeled by an FATP1-linked mechanism into the TG biosynthetic pathway; such internalized lipids downregulate de novo sphingomyelin and cholesterol metabolism in growing 293 cells PMID: 12235169
9. FATP1 might play a role in post-prandial lipid metabolism and development of cardiovascular disease. PMID: 12818409
10. FATP1 stimulated transport and consumption of palmitate and oleate, which they channeled away from complete oxidation and toward TAG synthesis. PMID: 15897321
11. These data reveals the localization and points to a regulatory function of FATP1 in myotube mitochondria. PMID: 19361580
12. Observational study of gene-disease association. (HuGE Navigator) PMID: 18660489
13. Observational study of gene-disease association. (HuGE Navigator) PMID: 12818409
14. Observational study of gene-disease association. (HuGE Navigator) PMID: 15978856
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亞細胞定位：

Cell membrane; Single-pass membrane protein. Endomembrane system; Single-pass membrane protein. Cytoplasm.
蛋白家族：

ATP-dependent AMP-binding enzyme family
組織特異性：

Highest levels of expression are detected in muscle and adipose tissue small, intermediate levels in small intestine, and barely detectable in liver. Expressed in brain gray matter.
數據庫鏈接：

HGNC: 10995

OMIM: 600691

KEGG: hsa:376497

STRING: 9606.ENSP00000252595

UniGene: Hs.363138

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