SLC26A2 Antibody

中文名稱：

SLC26A2兔多克隆抗體
貨號：

CSB-PA021525LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA021525LA01HU diluted at 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA021525LA01HU diluted at 1:300 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA021525LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC26A2 Polyclonal antibody
Uniprot No.：

P50443
基因名：

SLC26A2
別名：

SLC26A2 antibody; DTD antibody; DTDST antibody; Sulfate transporter antibody; Diastrophic dysplasia protein antibody; Solute carrier family 26 member 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sulfate transporter protein (614-739AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SLC26A2 Antibody (CSB-PA021525LA01HU)，的標記方式是Non-conjugated。對于SLC26A2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA021525LB01HU	SLC26A2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021525LC01HU	SLC26A2 Antibody, FITC conjugated
Biotin	CSB-PA021525LD01HU	SLC26A2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sulfate transporter. May play a role in endochondral bone formation.
基因功能參考文獻：
1. Two heterozygous mutations in SLC26A2 mutations occur in a three-generational family with cases of multiple epiphyseal dysplasias. PMID: 29024831
2. Results show that SLC26A2 expression is high in numerous tumor types and, provide evidence that it downregulates the TRAIL receptors, DR4 and DR5 which confers resistance to TRAIL. PMID: 28108622
3. slc26a2 is to be a critical otic gene whose dysfunction may induce hearing impairment PMID: 26375458
4. findings provide the first identification of autosomal dominant SLC26A2 mutations in patients with dysplastic spondylolysis, suggesting a new clinical entity in the pathogenesis of chondrodysplasia involving lumbosacral spine PMID: 26077908
5. Diastrophic dysplasia sulfate transporter (SLC26A2) is expressed in the adrenal cortex and regulates aldosterone secretion. PMID: 24591336
6. Up-regulation of SLC26A2 is associated with colorectal cancer. PMID: 24222123
7. A compound heterozygote SLC26A2 mutation is associated with robin sequence, mild limbs shortness, accelerated carpal ossification, and multiple epiphysial dysplasia PMID: 23840040
8. SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively. PMID: 23453247
9. 73% of autosomal-recessive multiple epiphyseal dysplasia patients were either homozygous, or compound heterozygous, for SLC26A2 mutations. PMID: 21922596
10. Solute carrier family 26 member a2 (Slc26a2) protein functions as an electroneutral SOFormula/OH-/Cl- exchanger regulated b PMID: 22190686
11. Mutations in the SLC26A2 gene causes diastrophic dysplasia. PMID: 21155763
12. Analysis suggests that, while the DTDST family of disorders contains at least seven different conditions, gene mutations appear to cause a phenotypic continuum. DTDST genotype alone is an imperfect predictor of clinical severity along this continuum. PMID: 21077202
13. New intermediate phenotype between MED and DD caused by compound heterozygous mutations in the DTDST gene is reported. PMID: 21077204
14. Characterize transport of oxalate and sulfate by human SLC26A2 and mouse Slc26a2 expressed in Xenopus oocytes. PMID: 20219950
15. Diminished DTDST expression through epigenetic silencing is associated with colon cancer. PMID: 20460514
16. DTDST function is crucial for the uptake of extracellular sulfate required for proteoglycan sulfation. PMID: 14692227
17. The effects of sulfur availablility on proteoglycan sulfation in mice transgenic for a mutation of this gene are reported. PMID: 16719839
18. This study found an association between single nucleotide polymorphisms of the SLC26A2 gene and juvenile idiopathic arthritis. PMID: 17393463
19. DTDST is upregulated by dexamethasone stimulation of HT1080 fibrosarcoma cells and is required for fibronectin (FN) extracellular matrix deposition by these cells. PMID: 18056413
20. A novel SLC26A2 mutation was found in all subjects, inserted by site-directed mutagenesis in a vector harbouring the SLC26A2 cDNA, and expressed in sulfate transport deficient Chinese hamster ovary (CHO) cells to measure sulfate uptake activity PMID: 18708426
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相關疾病：

Diastrophic dysplasia (DTD); Achondrogenesis 1B (ACG1B); Atelosteogenesis 2 (AO2); Multiple epiphyseal dysplasia 4 (EDM4)
亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

SLC26A/SulP transporter (TC 2.A.53) family
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 10994

OMIM: 222600

KEGG: hsa:1836

STRING: 9606.ENSP00000286298

UniGene: Hs.302738

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