SLC1A6 Antibody

說(shuō)明書

中文名稱：

SLC1A6兔多克隆抗體
貨號(hào)：

CSB-PA021437LA01HU
規(guī)格：

￥440
圖片：
Western blot
All lanes: SLC1A6 antibody at 2µg/ml + A375 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 62, 35 kDa
Observed band size: 62 kDa

Immunofluorescent analysis of Hela cells using CSB-PA021437LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA021437LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA021437LA01HU at dilution of 1:100
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SLC1A6 Polyclonal antibody
Uniprot No.：

P48664
基因名：

SLC1A6
別名：

SLC1A6 antibody; EAAT4Excitatory amino acid transporter 4 antibody; Sodium-dependent glutamate/aspartate transporter antibody; Solute carrier family 1 member 6 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Excitatory amino acid transporter 4 protein (149-271AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，SLC1A6 Antibody (CSB-PA021437LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SLC1A6 Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA021437LB01HU	SLC1A6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021437LC01HU	SLC1A6 Antibody, FITC conjugated
Biotin	CSB-PA021437LD01HU	SLC1A6 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate.
基因功能參考文獻(xiàn)：
1. Decreased SLC1A6 expression in neuregulin 1 risk variant may be an adaptive effect to restore glutamate signalling in schizophrenia patients. PMID: 22424243
2. A twofold difference in functional EAAT4 levels is sufficient to alter signaling to Bergman glia in reporter mice. PMID: 22302796
3. strate-dependent gating of anion channels associated with excitatory amino acid transporter 4. PMID: 21572047
4. a conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4) PMID: 20519505
5. At least one susceptibility locus for schizophrenia may be located within or nearby SLC1A6. PMID: 17221839
6. Independent, rather than cooperative anion conductance gating significantly alters predictions of the influence that EAAT4-mediated anion currents will have on synaptic transmission at low glutamate concentrations. PMID: 17360917
7. conclusion, maximal glutamate transport modulation by SGK1 is accomplished by direct EAAT4 stimulation and to a lesser extent by inhibition of intrinsic Nedd4-2. PMID: 17442044
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亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A6 subfamily
組織特異性：

Brain. Expressed densely and selectively in cell bodies of Purkinje cells.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 10944

OMIM: 600637

KEGG: hsa:6511

STRING: 9606.ENSP00000221742

UniGene: Hs.515217

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