SLC17A8 Antibody
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中文名稱：SLC17A8兔多克隆抗體
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貨號(hào)：CSB-PA107772
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規(guī)格：￥1100
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圖片：
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human cerebella tissue and Human cerebrum tissue lysates, Primary antibody: CSB-PA107772(SLC17A8 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) SLC17A8 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Solute carrier family 17 (vesicular glutamate transporter), member 8; DFNA25; VGLUT3
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Synthetic peptide of human SLC17A8
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
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基因功能參考文獻(xiàn)：
- Novel pathogenic splicing mutation in SLC17A8 gene identified in a family with hearing loss. PMID: 28647561
- A point mutation in VGLUT3 dramatically reduces its expression in synaptic terminals without altering its function. PMID: 28314816
- The results of this study identify VGLUT3 as an unexpected regulator of drug abuse. PMID: 26239290
- The results from our study suggest that the p.M206Nfs*4 mutation in the SLC17A8 gene is likely a pathogenic mutation that causes autosomal dominant non-syndromic hearing loss. PMID: 26797701
- The absence of VGLUT3 in transgenic mice leads to an up-regulation of the midbrain dopamine system and ameliorates motor dysfunction in a model of Parkinson's disease. PMID: 26558771
- human vesicular glutamate transporter 3 was cloned, shows 72% identity to both hVGLUT1 and hVGLUT2, and its expression in brain overlaps with hVGLUT1 and hVGLUT2 PMID: 12151341
- Docking and homology modeling explain the inhibition of VGLUT3. PMID: 17660252
- VGLUT3 immunoreactivity covered only a limited portion of the possible Glu-ergic pathways in the human fetal small intestine. PMID: 18498073
- SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction PMID: 18674745
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相關(guān)疾?。?/div>Deafness, autosomal dominant, 25 (DFNA25)亞細(xì)胞定位：Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome.蛋白家族：Major facilitator superfamily, Sodium/anion cotransporter family, VGLUT subfamily組織特異性：Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.數(shù)據(jù)庫鏈接：
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