SLC17A3 Antibody

中文名稱：

SLC17A3兔多克隆抗體
貨號：

CSB-PA021419LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA021419LA01HU at dilution of 1:100

Immunofluorescent analysis of Hela cells using CSB-PA021419LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SLC17A3 Polyclonal antibody
Uniprot No.：

O00476
基因名：

SLC17A3
別名：

SLC17A3 antibody; NPT4 antibody; Sodium-dependent phosphate transport protein 4 antibody; Na(+)/PI cotransporter 4 antibody; Sodium/phosphate cotransporter 4 antibody; Solute carrier family 17 member 3 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sodium-dependent phosphate transport protein 4 protein (1-125AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SLC17A3 Antibody (CSB-PA021419LA01HU)，的標記方式是Non-conjugated。對于SLC17A3 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA021419LB01HU	SLC17A3 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021419LC01HU	SLC17A3 Antibody, FITC conjugated
Biotin	CSB-PA021419LD01HU	SLC17A3 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

voltage-driven, multispecific, organic anion transporter able to transport para-aminohippurate (PAH), estrone sulfate, estradiol-17-beta-glucuronide, bumetanide, and ochratoxin A. Isoform 2 functions as urate efflux transporter on the apical side of renal proximal tubule and is likely to act as an exit path for organic anionic drugs as well as urate in vivo. May be involved in actively transporting phosphate into cells via Na(+) cotransport.
基因功能參考文獻：
1. Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004). PMID: 27772792
2. hNPT4 (SLC17A3) mediated time- and concentration-dependent uptake of OTxA (K(m): 802.8 microM) in a pH- and voltage-sensitive manner. PMID: 21778665
3. variants carrying SNP V257F, G279R, or P378L exhibited reduced transport of para-aminohippurate, bumetanide, estrone and urate; SNPs may contribute to inter-individual differences in disposition of anionic drugs and certain endogenous organic anions PMID: 21282933
4. Genetic variants within SLC2A9,ABCG2 and SLC17A3 are associated with uric acid levels PMID: 20053405
5. a model of urate secretion in the renal tubular cell, where intracellular urate taken up via OAT1 and/or OAT3 from the blood exits from the cell into the lumen via hNPT4. PMID: 20810651
6. SLC17A3 seems to have a major role in determination of serum uric acid repeated measurements variation. PMID: 20162743
7. mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase complex PMID: 15505377
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亞細胞定位：

[Isoform 1]: Endoplasmic reticulum membrane; Multi-pass membrane protein.; [Isoform 2]: Cell membrane; Multi-pass membrane protein.
蛋白家族：

Major facilitator superfamily, Sodium/anion cotransporter family
組織特異性：

Expressed in the liver and kidney. It is detected in proximal tubules in renal cortex as well as some tubules and glomeruli, with highest expression at the apical side of proximal tubules (at protein level).
數據庫鏈接：

HGNC: 10931

OMIM: 611034

KEGG: hsa:10786

STRING: 9606.ENSP00000380250

UniGene: Hs.327179

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