SKAP2 Antibody
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中文名稱：SKAP2兔多克隆抗體
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貨號：CSB-PA021355GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：SKAP2
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別名：Fyn associated phosphoprotein SKAP55 homologue antibody; MGC10411 antibody; MGC33 antibody; PRAP antibody; Pyk2/RAFTK associated protein antibody; Pyk2/RAFTK-associated protein antibody; RA70 antibody; Retinoic acid-induced protein 70 antibody; SAPS antibody; SKAP-55HOM antibody; SKAP-HOM antibody; skap2 antibody; SKAP2_HUMAN antibody; SKAP55 homolog antibody; SKAP55R antibody; Src associated adaptor protein antibody; Src family associated phosphoprotein 2 antibody; Src family-associated phosphoprotein 2 antibody; src kinase associated phosphoprotein of 55 related protein antibody; Src kinase-associated phosphoprotein 2 antibody; Src kinase-associated phosphoprotein 55-related protein antibody; Src-associated adapter protein with PH and SH3 domains antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human SKAP2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點詳情
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功能：May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway.
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基因功能參考文獻：
- Macrophages assemble the appropriate motile machinery to infiltrate tumors and promote disease progression, and implicate SKAP2 as an attractive candidate for therapeutically targeting TAMs. PMID: 26577701
- Skap2 is necessary for macrophage migration, chemotaxis, global actin reorganization and local actin reorganization upon integrin engagement. PMID: 22976304
- SKAP2 expression levels in NSCLC tissues could be a powerful biomarker of poor prognosis. Therefore, SKAP2 is a promising candidate molecular target for Non-small cell lung cancer treatment. PMID: 25862907
- results suggest that SKAP2 negatively regulates cell migration and tumor invasion in fibroblasts and glioblastoma cells by suppressing actin assembly induced by the WAVE2-cortactin complex PMID: 23161539
- analysis of substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate PMID: 21719704
- cloning & characterization of an adaptor protein that functions as a downstream target for RAFTK & plays a role in alpha-synuclein phosphorylation PMID: 12893833
- studies provide insights into the molecular mechanism ofrelated adhesion focal tyrosine kinase (RAFTK) autophosphorylation and the specific role of Src in the regulation of RAFTK activation PMID: 15166227
- Overexpression of SKAP2 is associated with the development of pancreatic ductal adenocarcinoma PMID: 17952125
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亞細胞定位：Cytoplasm.
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蛋白家族：SKAP family
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組織特異性：Ubiquitously expressed. Present in platelets (at protein level).
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數(shù)據(jù)庫鏈接：
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