SKAP1 Antibody

說明書

中文名稱：

SKAP1兔多克隆抗體
貨號：

CSB-PA021354GA01HU
規(guī)格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q86WV1
基因名：

SKAP1
別名：

pp55 antibody; SCAP 1 antibody; SCAP1 antibody; SKAP 1 antibody; SKAP 55 antibody; SKAP-55 antibody; Skap1 antibody; SKAP1_HUMAN antibody; SKAP55 adaptor protein antibody; SRC family associated phosphoprotein 1 antibody; Src family-associated phosphoprotein 1 antibody; Src kinase associated phosphoprotein 1 antibody; SRC kinase associated phosphoprotein 55 kD antibody; Src kinase associated phosphoprotein of 55 kDa antibody; Src kinase-associated phosphoprotein 1 antibody; Src kinase-associated phosphoprotein of 55 kDa antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SKAP55,SKAP1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells.
基因功能參考文獻：
1. K152 and D120 within the PH domain of SKAP55 regulate plasma membrane targeting and T cell receptor-mediated activation of LFA-1. PMID: 28052935
2. SKAP55 dimers stabilize SLP-76 microclusters, couple SLP-76 to the force-generating systems responsible for microcluster movement, and enable adhesion via the TCR by mechanisms independent of RIAM, talin, and beta1 integrins. PMID: 24368808
3. single-nucleotide polymorphisms in ARRDC3, FLT1, and SKAP1 were significant predictors for survival androgen-deprivation therapy in prostate cancer patients. PMID: 21652578
4. N-terminal myr-tagged SKAP1 for membrane binding facilitated constitutive RapL membrane and Rap1 binding and effectively substituted for PI3K and TCR ligation in the activation of LFA-1 in T cells. PMID: 21669874
5. Single nucleotide polymorphism in SKAP1 is associated with ovarian cancer. PMID: 20852632
6. findings define a T cell receptor "inside-out" pathway via N-SKAP1-C-RapL that regulates T cell adhesion, motility, and arrest times with dendritic cells in lymph nodes. PMID: 20346707
7. SKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcription. PMID: 11909961
8. observation that adapter protein SKAP55 formed homodimers through its SH3 domain and SK region PMID: 12171928
9. SKAP-55 regulates integrin-mediated adhesion and conjugate formation between T cells and antigen-presenting cells PMID: 12652296
10. stimuli that signal for the stabilization of SKAP55 may play an important role in T cell adhesion and conjugate formation PMID: 15849195
11. This study reports on a RKXXY294 motif in SKAP-55 that mediates unique ADAP SH3c domain binding; it is necessary for LFA-1-mediated adhesion and cytokine production. PMID: 16461356
12. These results suggest that SKAP55 modulates signal transduction from the T cell antigen receptor to Ras by binding to RasGRP1. PMID: 17658605
13. SKAP1 protein as a novel regulator of the metaphase-to-anaphase transition and demonstrates that misregulation of the separase activation results in a reduced fidelity of chromosome segregation and a reduced genomic stability independent of the SAC. PMID: 19667759
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亞細胞定位：

Cytoplasm. Nucleus. Cell membrane.
蛋白家族：

SKAP family
組織特異性：

Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).
數據庫鏈接：

HGNC: 15605

OMIM: 604969

KEGG: hsa:8631

STRING: 9606.ENSP00000338171

UniGene: Hs.316931

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