SIX6 Antibody

說明書

中文名稱：

SIX6兔多克隆抗體
貨號：

CSB-PA004096
規格：

￥1090
圖片：
Western Blot analysis of COLO205 cells using Six3/6 Polyclonal Antibody

Western Blot analysis of RAT-MUSCLE cells using Six3/6 Polyclonal Antibody
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O95475
基因名：

SIX6
別名：

Homeobox protein SIX6 antibody; Homeodomain protein OPTX2 antibody; MCOPCT 2 antibody; MCOPCT2 antibody; Optic homeobox 2 antibody; OPTX 2 antibody; OPTX2 antibody; Sine oculis homeobox homolog 6 antibody; SIX 6 antibody; Six 9 antibody; SIX homeobox 6 antibody; Six6 antibody; SIX6_HUMAN antibody; Six9 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from the Internal region of Human Six3/6.
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產品提供形式：

Liquid
應用范圍：

WB, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be involved in eye development.
基因功能參考文獻：
1. The results suggest that SIX6 influences different stages of RGC differentiation and their survival; therefore, alteration in SIX6 function due to the risk allele may lead to cellular and molecular abnormalities. PMID: 28792678
2. We replicated the association of SNP rs10483727 in the SIX1/SIX6 locus with POAG in a Saudi cohort, suggesting its role in increasing susceptibility to Primary Open Angle Glaucoma . PMID: 29190129
3. Among 8 SNPs in 3 loci that showed at least nominal association (P < 5.00E-02) in the primary cohort, a representative SNP for each loci (rs2157719 for CDKN2B-AS1, rs33912345 for SIX6, and rs9913911 for GAS7) were selected PMID: 29261660
4. elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC and poor relapse-free survival (RFS) in lung adenocarcinoma PMID: 27821176
5. study replicated the association of POAG with two SNPs at the SIX1-SIX6 locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG in patients aged above 40 years PMID: 27260188
6. Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of RPL26. PMID: 26687066
7. Single nucleotide polymorphism in SIX6 gene is associated with primary open angle glaucoma. PMID: 25798827
8. SIX6 and/or intraocular pressure promotes primary open-angle glaucoma by directly increasing p16INK4a expression. PMID: 26365380
9. we report a homozygous missense mutation of SIX6 associated with a unique eye phenotype characterized by optic disc anomalies, macular atrophy, and coloboma of the iris and chorioretina. PMID: 24702266
10. Nonglaucomatous individuals with the SIX6 missense variant have reduced RNFL thickness in regions known to be particularly affected in those with glaucoma. PMID: 25537207
11. Our results, in combination with previous SIX6 work, lead us to hypothesize that SIX6 risk variants disrupt the development of the neural retina, leading to a reduced number of retinal ganglion cells. PMID: 24875647
12. Our findings in humans and zebrafish suggest a functional involvement of six6b in early eye development, and open new insights into the genetic architecture of POAG. PMID: 24150847
13. No evidence was found that SIX6 mutations underlie human congenital structural eye malformations. PMID: 15505031
14. Six6 and Six2 differ in their DNA-binding mechanisms and in the consequences of their interaction with protein tyrosine phosphatase Eyes Absent in Six2/6-DNA-binding ability. PMID: 18293925
15. BOR and OAVS features are associated with duplication of SIX1, SIX6 and OTX2 resulting from a complex chromosomal rearrangement. PMID: 18666230
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相關疾病：

Optic disk anomalies with retinal and/or macular dystrophy (ODRMD)
亞細胞定位：

Nucleus.
蛋白家族：

SIX/Sine oculis homeobox family
組織特異性：

Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions.
數據庫鏈接：

HGNC: 10892

OMIM: 212550

KEGG: hsa:4990

STRING: 9606.ENSP00000328596

UniGene: Hs.194756

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