SIK1 Antibody

中文名稱：

SIK1兔多克隆抗體
貨號：

CSB-PA021321LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA021321LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA021321LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA021321LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SIK1 Polyclonal antibody
Uniprot No.：

P57059
基因名：

SIK1
別名：

KID2 antibody; MSK antibody; myocardial SNF1 like kinase antibody; QIK antibody; Qin-induced kinase antibody; Salt inducible kinase 1 antibody; Salt-inducible protein kinase 1 antibody; Serine threonine protein kinase SNF1 like kinase 1 antibody; Serine threonine protein kinase SNF1LK antibody; Serine/threonine-protein kinase SIK1 antibody; Serine/threonine-protein kinase SNF1-like kinase 1 antibody; Serine/threonine-protein kinase SNF1LK antibody; SIK-1 antibody; SIK1 antibody; SIK1_HUMAN antibody; SNF1 like kinase antibody; Snf1lk antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Serine/threonine-protein kinase SIK1 protein (492-750AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SIK1 Antibody (CSB-PA021321LA01HU)，的標記方式是Non-conjugated。對于SIK1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA021321LB01HU	SIK1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA021321LC01HU	SIK1 Antibody, FITC conjugated
Biotin	CSB-PA021321LD01HU	SIK1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, CRTC1/TORC1. Inhibits CREB activity by phosphorylating and inhibiting activity of TORCs, the CREB-specific coactivators, like CRTC2/TORC2 and CRTC3/TORC3 in response to cAMP signaling. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators CRTC1/TORC1 and CRTC2/TORC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1. In concert with CRTC1/TORC1, regulates the light-induced entrainment of the circadian clock by attenuating PER1 induction; represses CREB-mediated transcription of PER1 by phosphorylating and deactivating CRTC1/TORC1.
相關疾病：

Epileptic encephalopathy, early infantile, 30 (EIEE30)
亞細胞定位：

Cytoplasm. Nucleus. Note=Locates to cytoplasm when inactive following cAMP-induced phosphorylation, probably by PKA (PubMed:29211348).
蛋白家族：

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, AMPK subfamily
數據庫鏈接：

HGNC: 11142

OMIM: 605705

KEGG: hsa:102724428

STRING: 9606.ENSP00000270162

UniGene: Hs.282113

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