SH3GL2 Antibody
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中文名稱：SH3GL2兔多克隆抗體
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貨號：CSB-PA860785DSR1HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA860785DSR1HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SH3GL2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：bA335L15.1 (SH3 domain GRB2 like 2) antibody; CNSA2 antibody; EEN B1 antibody; EEN-B1 antibody; Endophilin 1 antibody; Endophilin A1 antibody; Endophilin A1 BAR domain antibody; Endophilin-1 antibody; Endophilin-A1 antibody; FLJ20276 antibody; FLJ25015 antibody; OTTHUMP00000021084 antibody; SH3 domain containing GRB2 like protein 2 antibody; SH3 domain GRB2 like 2 antibody; SH3 domain protein 2A antibody; SH3 domain-containing GRB2-like protein 2 antibody; SH3D2A antibody; SH3G2_HUMAN antibody; Sh3gl2 antibody; Sh3p4 antibody; SH3PA antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Endophilin-A1 protein (1-270AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
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靶點詳情
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功能：Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
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基因功能參考文獻：
- The results suggest that SH3GL2 suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3/MMP2 signaling. PMID: 28470949
- Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration. PMID: 27244115
- This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2. These proteins were frequently lost in breast cancer, which was traceable in the circulating exosomes. PMID: 26888829
- Endophilin-1 was a direct and functional downstream target of miR-107. PMID: 27038654
- Methylation status of SH3GL2 gene was associated with the TNM staging and HPV infection status of vulvar squamous cell carcinoma. PMID: 26823912
- Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR-JNK signaling pathway in hCMEC/D3 cells, which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier . PMID: 25721793
- these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
- Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC). PMID: 25728707
- study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway PMID: 24854121
- miR-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK and PI3K/AKT signaling pathways. PMID: 24736727
- these findings identify loss of Sh3gl2 as a frequent event in Urothelial carcinoma (UC) development that promotes disease progression. PMID: 23814487
- this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin. PMID: 24076656
- Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. PMID: 23675485
- Data suggest that expression of endothelin-1 and vWF (von Willebrand factor) is up-regulated and eNOS (endothelial nitric oxide synthase) activity is increased in radial artery in diabetic patients with coronary artery disease. PMID: 22972845
- Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function. PMID: 22968441
- SH3GL2 gene was identified as the target of miR-330. miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma. PMID: 23029364
- simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1 PMID: 21829671
- Alterations of SH3GL2 and CDKN2A loci have a synergistic role in the development of early-onset breast cancer. PMID: 18239974
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亞細胞定位：Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.
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蛋白家族：Endophilin family
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組織特異性：Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
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數據庫鏈接：
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