SH2D2A Antibody

說明書

中文名稱：

SH2D2A兔多克隆抗體
貨號：

CSB-PA003129
規(guī)格：

￥1090
圖片：
Western Blot analysis of HepG2 cells using Lad Polyclonal Antibody
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9NP31
基因名：

SH2D2A
別名：

F2771 antibody; SCAP antibody; SH2 domain containing adapter protein antibody; SH2 domain containing protein 2A antibody; SH2 domain protein 2A antibody; SH2 domain-containing adapter protein antibody; SH2 domain-containing protein 2A antibody; SH22A_HUMAN antibody; Sh2d2a antibody; T cell specific adapter protein antibody; T cell specific adapter protein TSAd antibody; T cell specific adpater protein TSAd antibody; T cell-specific adapter protein antibody; T lymphocyte specific adaptor protein antibody; TSAd antibody; VEGF receptor associated protein antibody; VEGF receptor-associated protein antibody; VRAP antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human Lad.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation.
基因功能參考文獻：
1. Data indicate that the T cell-specific adaptor protein (TSAd) SH2 domain interacts with CD6 antigen and linker for activation of T cells protein (LAT) phosphotyrosine (pTyr) peptides. PMID: 27896837
2. TSAD binds to and co-localizes with Nck. Expression of TSAD increases both Nck-Lck and Nck-SLP-76 interaction in T cells. PMID: 26163016
3. The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. PMID: 25492967
4. Data indicate the expression pattern of T cell-specific adapter protein (TSAd) in various healthy lymphoid and non-lymphoid tissues. PMID: 24910151
5. in chronic inflammatory demyelinating polyneuropathy we found an association with a homozygous genotype for a low repeat number of tandem GA in the SH2D2A gene PMID: 21696499
6. TSAd, through its interaction with both Itk and Lck, primes Itk for Lck mediated phosphorylation and thereby regulates CXCL12 induced T cell migration and actin cytoskeleton rearrangements PMID: 20305788
7. TSAd associates with laminin binding protein and mediates T lymphocyte migration during T cell activation PMID: 19561400
8. 'short' alleles of the promoter could contribute to the genetic susceptibility to Juvenile Rheumatoid Arthritis PMID: 15129233
9. TSAd appears to contribute to interleukin-2 synthesis at multiple different levels PMID: 15752554
10. upon chemokine stimulation, Lad acts as an adaptor protein that links the G protein beta subunit to the tyrosine kinases Lck and Zap-70, thereby mediating T-cell migration PMID: 17327418
11. SH2D2A expression is regulated both at the transcriptional and translational level. PMID: 18160104
12. This study found a significant association between CIDP and the genotype GA13-16 homozygote (OR 3.167; p 0.013). PMID: 18533279
13. lymphocyte-specific protein tyrosine kinase binds to T cell-specific adapter protein (TSAd) prolines and phosphorylates and interacts with the three C-terminal TSAd tyrosines PMID: 18541536
14. the present study shows that the SH2D2A gene may contribute to susceptibility to MS. PMID: 18554728
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亞細(xì)胞定位：

Cytoplasm.
組織特異性：

Expression limited to tissues of the immune system and, in particular, activated T-cells. Expressed in peripheral blood leukocytes, thymus and spleen. Much lower expression or undetectable, in brain, placenta, skeletal muscle, prostate, testis, ovary, sma
數(shù)據(jù)庫鏈接：

HGNC: 10821

OMIM: 604514

KEGG: hsa:9047

STRING: 9606.ENSP00000376123

UniGene: Hs.103527

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