SGCG Antibody

中文名稱：

SGCG兔多克隆抗體
貨號：

CSB-PA618771LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA618771LA01HU diluted at 1:500 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA618771LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SGCG Polyclonal antibody
Uniprot No.：

Q13326
基因名：

SGCG
別名：

35 kDa dystrophin associated glycoprotein antibody; 35 kDa dystrophin-associated glycoprotein antibody; 35DAG antibody; 35kD dystrophin associated glycoprotein antibody; 35kDa dystrophin-associated glycoprotein antibody; A4 antibody; DAGA4 antibody; DMDA antibody; DMDA1 antibody; Gamma SG antibody; Gamma-sarcoglycan antibody; Gamma-SG antibody; LGMD2C antibody; MAM antibody; MGC130048 antibody; Sarcoglycan gamma antibody; SCARMD2 antibody; SCG3 antibody; SGCG antibody; SGCG_HUMAN antibody; TYPE antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Gamma-sarcoglycan protein (108-221AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SGCG Antibody (CSB-PA618771LA01HU)，的標記方式是Non-conjugated。對于SGCG Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA618771LB01HU	SGCG Antibody, HRP conjugated	ELISA
FITC	CSB-PA618771LC01HU	SGCG Antibody, FITC conjugated
Biotin	CSB-PA618771LD01HU	SGCG Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
基因功能參考文獻：
1. This study showed that fifteen families were shown to carry SGCG variants in patient with early onset severe muscular dystrophy. PMID: 27759885
2. FADH2-dependent monooxygenase (SgcE6 and SgcC) that catalyzes the hydroxylation of a PCP-tethered substrate PMID: 27560143
3. These results position archvillin as a mechanically sensitive component of the dystrophin complex and demonstrate that signaling defects caused by loss of gamma-SG occur both at the sarcolemma and in the nucleus. PMID: 25605665
4. A report of two siblings with severe childhood onset limb-girdle muscular dystrophy type 2C supports the theory that the mutation G787A in the SGCG gene is a founder mutation. PMID: 24534832
5. Molecular epidemiologic methods were used to calculate the frequency of heterozygotes for this SGCG mutation in Moroccan newborns and to estimate the prevalence of LGMD2C in the Moroccan population. PMID: 24552312
6. Data suggest that an SNP in an intron of SGCG (rs9552911) is associated with type 2 diabetes [Genome-Wide Association Study in Sikh populations in India & Meta-Analysis] PMID: 23300278
7. The C allele of the c.-94C>G polymorphism in delta-sarcoglycan is a risk factor for HCM, which is increased by the Amerindian component and can play an important role in the etiology and progression of disease in Mexican patients PMID: 22524166
8. four Greek Gypsy patients with limb girdle muscular dystrophy type 2C carried the same homozygous C283Y mutation in the gamma-sarcoglycan gene PMID: 20345928
9. The relative incidence of LGMD2C among Japanese Duchenne muscular dystrophy-like patients can be calculated as 1 in 161 patients suspected to have Duchenne muscular dystrophy. PMID: 20350330
10. Clinical, histologic, and immunohistochemical characteristics of three children with limb-girdle muscular dystrophy type 2C. Two novel mutations in the gamma-sarcoglycan gene were present. We found phenotypic differences in two brothers. PMID: 15087111
11. two unrelated patients of Puerto Rican descent who have identical previously undescribed homozygous E263K (G787A) missense mutations on exon 8, and a white North American child with del521T on one allele and a deletion of exon 6 on the other allele. PMID: 16832103
12. The limb-girdle muscular dystrophy patients with gamma-sarcoglycan deficient LGMD2C do not enable an accurate prediction of the genotype. PMID: 18996010
13. This study, the first mutational analysis of Indian patients with sarcoglycanopathies suggests gamma SG mutations were the most common and the most prevalent mutation in the gamma SG gene was 525del.T. PMID: 19770540
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相關疾病：

Limb-girdle muscular dystrophy 2C (LGMD2C)
亞細胞定位：

Cell membrane, sarcolemma; Single-pass type II membrane protein. Cytoplasm, cytoskeleton.
蛋白家族：

Sarcoglycan beta/delta/gamma/zeta family
組織特異性：

Expressed in skeletal and heart muscle.
數據庫鏈接：

HGNC: 10809

OMIM: 253700

KEGG: hsa:6445

STRING: 9606.ENSP00000218867

UniGene: Hs.37167

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