SFTPA2 Antibody
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中文名稱：SFTPA2兔多克隆抗體
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貨號(hào)：CSB-PA005109
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of K562 mouse lung cells using SP-A Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：SFTPA2
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別名：SFTPA2 antibody; COLEC5 antibody; PSAP antibody; SFTP1 antibody; SFTPA antibody; SFTPA2B antibody; Pulmonary surfactant-associated protein A2 antibody; PSP-A antibody; PSPA antibody; SP-A antibody; SP-A2 antibody; 35 kDa pulmonary surfactant-associated protein antibody; Alveolar proteinosis protein antibody; Collectin-5 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human SP-A.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:20000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
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基因功能參考文獻(xiàn)：
- SP-A1 6A4 and SP-A2 1A5 genetic variants may influence the susceptibility to respiratory distress syndrome in late-preterm infants, independently of the effect of other perinatal factors. PMID: 27835691
- Significant differences in frequency of occurrence of unfavorable genotypes CC rs1965708, AA rs1059046 of SFTPA2 gene and CC rs1130866 of SFTPB gene in influenza patients in comparison with individuals of the control group were not detected. PMID: 26950992
- In a Dutch cohort study of unrelated patients with idiopathic or familial interstitial pneumonia genetic analysis of SFTPA2 three new mutations in exon 6 of SFTPA2: N210T, G231R, and N171Y were identified. None were found in the control group. PMID: 26568241
- Investigated the relationship between SP-A2 and SP-B gene polymorphisms and respiratory distress syndrome in preterm neonates. PMID: 26061924
- Expression of SFTPA2 mRNA and total SP-A protein was significantly lower in cancer tissue. PMID: 25514367
- In this study, the loci and haplotypes associated with pulmonary tuberculosis (PTB) were found mostly to be located in the SFTPA2 gene, suggesting that the effects of the SFTPA2 gene on PTB are stronger than those of SFTPA1. PMID: 24984162
- Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses. PMID: 25957169
- data suggest an effect of genetic variants of SFTPA2 on the severity of pandemic H1N1 infection PMID: 24950659
- This study shows that changes occur in the alveolar macrophage proteome in response to a single in vivo treatment with exogenous SP-A1 and/or SP-A2. PMID: 24954098
- In this review, we highlight the associations of eosinophilic lung diseases with SP-A and SP-D levels and functions. PMID: 24960334
- sequence variability at the 3'UTR of SFTPA1 and SFTPA2 gene variants differentially affects miRNA regulation of gene expression. PMID: 24793167
- The aim of this report is to describe the genetic complexity of the SFTPA1 and SFTPA2 genes, as well as to review regulatory mechanisms that control SP-A expression in humans and other animal species.[review] PMID: 23069847
- findings show rs1650232 is in partial linkage disequilibrium with known SP-A2 marker single-nucleotide polymorphisms previously associated with risk for respiratory diseases including tuberculosis PMID: 23328842
- proteins including the 14-3-3 family bind two cis-elements within exon B of hSP-A2 mRNA in a sequence- and secondary structure-specific manner. PMID: 23525782
- SP-A2 G231V and F198S mutants impair the dimmer/trimer assembly, which contributes to the protein sialylation and secretion deficiency. The intracellular protein mutants could be partially degraded through the proteasome pathway and formed aggregates PMID: 23056344
- Surfactant protein A associated with respiratory distress syndrome in Korean preterm infants: evidence of ethnic difference. PMID: 23038062
- The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation. PMID: 21840962
- there is an association of risk for severe acute respiratory syncytial infection in variant forms of the surfactant protein A2 allele PMID: 21601013
- These results indicate that the gene polymorphism at the residue 223 in the carbohydrate recognition domain of SFTPA2 may be a genetic marker for the development of allergic rhinitis in the adult Chinese Han population. PMID: 20963503
- The mechanism of pulmonary fibrosis does not involve an overt lack of secreted SP-A but instead involves an increase in endoplasmic reticulum stress of resident type II alveolar epithelial cells. PMID: 20466729
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20448439
- Electron microscopy analysis revealed that hTG mice with a single SP-A1(6A(4)) or SP-A2(1A(3)) gene product lacked tubular myelin (TM), but hTG mice carrying both had TM. PMID: 20048345
- SP-A2 polymorphisms are associated with the severity of respiratory syncytial virus infection in infants PMID: 19914637
- Decreased levels of SP-A and SP-D have been measured in bronchoalveolar lavage fluid of these patients, as well as patients with acute pneumonia but no chronic lung disease. (review) PMID: 16406431
- We conclude that SP-A permeabilizes phospholipid membranes in an LPS-dependent and rough LPS-specific manner, that the effect is neither SP-A- nor species-specific, and that oxidative damage to SP-A abolishes its membrane destabilizing properties PMID: 16489761
- Residue 85 plays an important role in the structure and function of SP-A and is a major factor for the differences between SP-A1 and SP-A2 variants. PMID: 17580966
- TTF-1 response element is critical for temporal and spatial regulation and necessary for hormonal regulation of human surfactant protein-A2 promoter activity PMID: 18487360
- The amniotic fluid concentration of SP-A decreases in spontaneous human parturition at term. PMID: 18828058
- These data are consistent with SFTPA2 germline mutations that interfere with protein trafficking and cause familial IPF and lung cancer. PMID: 19100526
- SP-A1 and SP-A2, in addition to their roles in surfactant-related functions, play an important role in the modulation of lung host defense. PMID: 19392648
- Observational study of gene-disease association. (HuGE Navigator) PMID: 16385451
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19543369
- Observational study of gene-disease association. (HuGE Navigator) PMID: 18983439
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相關(guān)疾病：Pulmonary fibrosis, idiopathic (IPF)
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
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蛋白家族：SFTPA family
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