SERPIND1 Antibody

說明書

中文名稱：

SERPIND1兔多克隆抗體
貨號：

CSB-PA788694
規格：

￥2024
圖片：
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Heparin Cofactor II antibody.

Immunofluorescence analysis of HepG2 cells, using Heparin Cofactor II antibody.
其他：

產品詳情
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相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SERPIND1 Polyclonal antibody
Uniprot No.：

P05546
基因名：

SERPIND1
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from internal of Human Heparin Cofactor II.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC,IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:50-1:100
IF	1:100-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.; Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
基因功能參考文獻：
1. Loss of Heparin Cofactor is associated with insulin resistance . PMID: 28502917
2. The plasma level of alpha2M was found positively correlated, while HCII level was negatively correlated with higher vulnerability of carotid plaques. Both proteins were efficient in differentiating stable and vulnerable carotid plaques. These provide potential new targets for the research of carotid plaque vulnerability. Plasma alpha2M and HCII may be potential biomarkers for evaluation of the vulnerability of carotid ... PMID: 28087279
3. We found that SERPIND1 may act as a potential oncogene in the development of ovarian cancer PMID: 27430660
4. Molecular modelling of HCII 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67. PMID: 23496873
5. heparin co-factor II is a novel metastasis enhancer and may be used as a prognostic predictor for heparin treatment in non-small cell lung cancer PMID: 25130770
6. In this study, we demonstrate a previously unknown role for HCII in host defense. PMID: 23656734
7. HCII potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK-eNOS signaling pathway. PMID: 22904320
8. Plasma heparin cofactor II activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction. PMID: 21107326
9. [REVIEW]HCII protects against vascular remodeling, including atherosclerosis PMID: 20671370
10. potential for oversulfated disaccharides in controlling HCII-regulated thrombin generation PMID: 20053992
11. Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II promote PMID: 11856753
12. role of basic amino acids of the A helix of heparin cofactor II in heparin- or dermatan sulfate-mediated thrombin inhibition. PMID: 12095635
13. Altering heparin cofactor II at VAL439 (P6) either impairs inhibition of thrombin or confers elastase resistance. PMID: 12152684
14. The interactions of HCII with various heparins in solution competition experiments using SPR show that while calcium enhances this interaction, the activity of heparin-HCII complex against thrombin is not calcium dependent but can be enhanced by it. PMID: 15247982
15. An asymptomatic Glu428Lys mutation affecting a conserved glutamate at the hinge (P17) of the reactive loop confirms the key structural role of the P17 glutamate in serpins. PMID: 15337701
16. after receiving stent for peripheral artery disease, patients with a high HCII activity had a 0.39-fold reduced risk for instent restenosis PMID: 15543340
17. HCII activity increases during pregnancy, and HCII levels are significantly decreased in women with severe pre-eclampsia. PMID: 16339402
18. Plasma heparin cofactor II activity is an independent predictor of future cardiovascular events in patients after acute myocardial infarction. PMID: 18971786
19. These results suggest that HCII is in a position to inhibit thrombin in atherosclerotic lesions where thrombin can exert a proatherogenic inflammatory response. PMID: 19747479
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相關疾病：

Thrombophilia due to heparin cofactor 2 deficiency (THPH10)
蛋白家族：

Serpin family
組織特異性：

Expressed predominantly in liver. Also present in plasma.
數據庫鏈接：

HGNC: 4838

OMIM: 142360

KEGG: hsa:3053

STRING: 9606.ENSP00000215727

UniGene: Hs.474270

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