SERPINA7 Antibody

說明書

中文名稱：

SERPINA7兔多克隆抗體
貨號：

CSB-PA532216
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA532216(SERPINA7 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA532216(SERPINA7 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產(chǎn)品詳情
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

P05543
基因名：

SERPINA7
別名：

Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 antibody; Serpin A7 antibody; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 7 antibody; Serpin peptidase inhibitor, clade A, member 7 antibody; Serpina7 antibody; T4 binding globulin antibody; TBG antibody; TBG, serum antibody; THBG_HUMAN antibody; Thyroxin binding globulin antibody; Thyroxine binding globulin antibody; Thyroxine-binding globulin antibody; Thyroxine-binding globulin od serum antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Full length fusion protein
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Major thyroid hormone transport protein in serum.
基因功能參考文獻(xiàn)：
1. A new SERPINA7 variant associated with thyroxine-binding globulin deficiency in three siblings. PMID: 29733970
2. THBG is a potential plasma biomarker for COPD. PMID: 28579773
3. mutation in a liver-specific enhancer region of the TBG gene caused inherited TBG deficiency. To our knowledge, the present study is the first report of an inherited endocrine disorder caused by a mutation in an enhancer region. PMID: 25361180
4. TBG allosteric regulation is entropy driven. The presence of multiple S states may allow more efficient T4 release due to protease activity. PMID: 23458682
5. the TBG promoter has a role in sustaining transgene expression in liver-specific pattern PMID: 22820390
6. Allosteric modulation of hormone release from thyroxine and corticosteroid-binding globulins. PMID: 21325280
7. Freshly isolated TBG-Chicago exists in loop expelled conformation. At 37C, the protein readily converts to a more stable loop inserted conformation with enhanced heat stability. PMID: 20429632
8. an intragenic A/G polymorphism (125 bp upstream from exon 2) was identified. complete TBG deficiency was homozygous for the polymorphic TBG allele. PMID: 11889160
9. Two novel variants in the thyroxine-binding globulin gene behind the diagnosis of TBG deficiency. homozygous. One involved codon 23 (TCA-->TAA) and the other, codon 223. PMID: 11916615
10. Loop variants of the serpin thyroxine-binding globulin: implications for hormone release upon limited proteolysis. PMID: 11931635
11. guanine deletion at position 1711, codon 201 (Asp) in exon 2 (GAC --> AC) led to a frame shift and premature termination at codon 206, causing a short TBG protein of 205 amino acids (AA) compared to 395 AA of the normal TBG. PMID: 17887925
12. new serpina7 gene variant in three members of the same family results in the replacement of the normal asparagine 233 by isoleucine and, subsequently, in disruption of a glycosylation site PMID: 19415532
13. The first exon (exon 0) is a short noncoding sequence located 1.62 kilobase pairs (kbp) upstream from exon 1. HNF-1 site (located 65 bp upstream of the TSS) is required for the hepatocyte specific expression of the hTBG gene. PMID: 8232304
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亞細(xì)胞定位：

Secreted.
蛋白家族：

Serpin family
組織特異性：

Expressed by the liver and secreted in plasma.
數(shù)據(jù)庫鏈接：

HGNC: 11583

OMIM: 300932

KEGG: hsa:6906

STRING: 9606.ENSP00000329374

UniGene: Hs.76838

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