SERBP1 Antibody

說明書

中文名稱：

SERBP1兔多克隆抗體
貨號：

CSB-PA021038GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q8NC51
基因名：

SERBP1
別名：

CGI 55 antibody; CHD3IP antibody; Chromodomain helicase DNA binding protein 3 interacting protein antibody; DKFZp564M2423 antibody; FLJ90489 antibody; HABP4L antibody; PAI 1 mRNA binding protein antibody; PAI RBP1 antibody; PAI-RBP1 antibody; PAI1 RNA-binding protein 1 antibody; PAIRB_HUMAN antibody; PAIRBP1 antibody; Plasminogen activator inhibitor 1 RNA binding protein antibody; Plasminogen activator inhibitor 1 RNA-binding protein antibody; Serbp1 antibody; SERPINE1 mRNA binding protein 1 antibody; SERPINE1 mRNA-binding protein 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SERBP1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,IHC
Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation.
基因功能參考文獻：
1. All these results suggested that miR-218/SERBP1 signal pathway could inhibit the malignant phenotype formation and that targeting this pathway may be a potential novel way for HCC therapeutics. PMID: 28369267
2. Data indicate that serpine1 messenger RNA (mRNA) binding protein 1 (SERBP1) was identified as a downstream target of microRNA miR-26a-5p. PMID: 27449037
3. SERBP1 is a component of the LRH-1 transcriptional complex. PMID: 26398198
4. PAI-RBP1 expression level is higher in non-small lung cancer tissues than in normal tissues. PMID: 22373659
5. Pseudomyogenic haemangioendothelioma consistently displays a SERPINE1-FOSB fusion gene, resulting from a translocation between chromosomes 7 and 19. PMID: 24374978
6. The RNA-binding protein SERBP1 is abundantly expressed in human breast cancer and may represent a novel breast tumour marker with prognostic significance PMID: 23236990
7. The RG-rich and RGG box of SERBP1 is asymmetrically dimethylated by PRMT1 and the modification affects protein interaction and intracellular localization of the protein. PMID: 22442049
8. The 4G allele of the 4G/5G polymorphism in the PAI-1 gene may be a risk factor for IgE-mediated asthma and allergic diseases. PMID: 11972486
9. Polymorphism of the PAI-1 gene promoter does not influence the development of AAA. However, the effect of PAI-1 genotype (5G5G) appears protective on survival following open aneurysm repair. PMID: 12027469
10. We observed that CGI-55 localizes to the nucleolus and co-localizes with p80-coilin positive nuclear-coiled bodies. PMID: 16679534
11. Has two conserved Gly/Arg-rich motif clusters (RGG/RXR box, where X is any amino acid) that may be substrates for arginine-methylation by protein arginine-methyltransferase-1 (PRMT1). PMID: 16879614
12. The presence of the genotype risk factors alone does not seem to be associated with the development of preeclampsia even in the severe presentation form. PAI-1 gene polymorphisms on the development of the preeclampsia was indicated. PMID: 16963292
13. In ovarian cancer, PAI-RBP1 is significantly overexpressed in tumor epithelial cells, suggesting a biological role in tumor invasion and metastasis. Its expression is higher in advanced disease. PMID: 17698176
14. This gene encodes a protein, PAI-RBP1, that binds to an RNA sequence (cyclic nucleotide responsive sequence, CRS) in the plasminogen activator-inhibitor (PAI-1) mRNA that confers cAMP regulation of mRNA stability. PMID: 11001948
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亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, perinuclear region.
組織特異性：

Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain.
數據庫鏈接：

HGNC: 17860

OMIM: 607378

KEGG: hsa:26135

STRING: 9606.ENSP00000360034

UniGene: Hs.530412

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