SEPT7 Antibody

說明書

中文名稱：

SEPT7兔多克隆抗體
貨號：

CSB-PA933190
規格：

￥2024
圖片：
Western blot analysis of extracts from MCF-7 cell, HuvEc cells and HeLa cells, using SEPT7 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SEPT7 Polyclonal antibody
Uniprot No.：

Q16181
基因名：

SEPT7
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Synthesized peptide derived from internal of Human SEPT7.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation.
基因功能參考文獻：
1. The present study identified that SEPT7 was a potential target of miR5903p and demonstrated that SEPT7 is associated with mediating the proapoptotic effect of miR5903p in human osteoblast cell line hFOB 1.19. PMID: 29568931
2. SEPT7 overexpression and knockdown sept7 protein suppress the expression of 78 kDa glucoseregulated protein (GRP78), C/EBPhomologous protein (CHOP), pro-caspase3 and cleaved caspase3 and eIf 2alpha protein. PMID: 29344665
3. Study discloses both SEPT2 and SEPT7 are essential for breast cancer cell migration and invasion by controlling MEK/ERK MAPKs activation. PMID: 27557506
4. SUMOylation of human septins is critical for septin filament bundling and cytokinesis. PMID: 29051266
5. Low SEPT7 expression is associated with glioma cell invasion. PMID: 27006177
6. The results of this study found that bipolar Neural crest cells progenitors lose their polarity, retracting their processes to round for division, but generate neurons with bipolar morphology by emitting processes from the same locations as the progenitor. PMID: 28817802
7. Results show that SEPT7 is involved in glioma cell migration with the assistance of cofilin phosphomediated cytoskeleton locomotion. PMID: 26846171
8. Septin6 and Septin7 GTP binding proteins regulate AP-3- and ESCRT-dependent multivesicular body biogenesis PMID: 25380047
9. Significantly lower SEPT7 expression in all expressional categories in encapsulated papillary thyroid carcinoma, follicular variant group may be a sign of different molecular signature in this type of tissue. PMID: 24685401
10. In response to Candida albicans infection, SEPT7 forms a complex with endothelial cell N-cadherin, is required for normal accumulation of N-cadherin around hyphae, and is necessary for maximal fungal endocytosis. PMID: 24345743
11. Significantly lower SEPT7 expression in encapsulated follicular variant of papillary thyroid carcinoma may be a sign of different molecular signature in this type of tissue. PMID: 24685401
12. SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9. PMID: 23572511
13. miR-30a-5p is a bona fide negative regulator of SEPT7 and the oncogenic activity of miR-30a-5p in human gliomas is at least in part through the repression of SEPT7 PMID: 23383034
14. Myeloid K562 cells express three SEPT9 isoforms, all of which have an equal propensity to hetero-oligomerize with SEPT7-containing hexamers to generate octameric heteromers. PMID: 22956766
15. Mutagenic analyses revealed that mutation of a potential phosphorylation site in SEPT7 (Y318) regulates the interaction with other septins. PMID: 21767235
16. the purification, crystallization and structure for the GTP-binding domain of human septin 7 PMID: 22064074
17. Sept7 occupies the ends of hexameric building blocks which assemble into non-polarised filaments. PMID: 21824007
18. The SEPT7 provides the directional guidance cues necessary for polarizing the epithelial microtubule network. PMID: 21788367
19. Data show that Septins of the SEPT6 group preferentially interacted with septins of the SEPT2 group, SEPT3 group and SEPT7 group. PMID: 21082023
20. SEPT7 gene expression is decreased in follicular variant of papillary thyroid carcinoma. PMID: 21509594
21. SEPT7 is involved in the regulation of sperm maturation. PMID: 20352323
22. The expression of SEPT7 mRNA was significantly decreased by 6.9% in subjects with schizophrenia. PMID: 20385374
23. This study demonstrates that SEPT7 is involved in gliomagenesis and suppresses glioma cell growth. PMID: 20035367
24. SEPT7 plays an important role in the glioma cell invasion. PMID: 19916744
25. regulated but the expression of CDK9, CDC20 and CLK3 was down- regulated in azoospermic testes. PMID: 19426592
26. Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption PMID: 15485874
27. septin 2, 6, and 7 complexes make up polymerized filaments PMID: 16914550
28. crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex PMID: 17637674
29. Demonstrate connection between septins/SOCS7/NCK signaling and the DNA damage response. PMID: 17803907
30. SEPT7 forms a link between kinetochore distribution of CENP-E and the mitotic spindle checkpoint. PMID: 18460473
31. SEPT7 gene can inhibit the invasion and migration ability of U251 glioma cells by reversing imbalanced state of MMPs/TIMPs, downregulating expression of integrin alpha(v)beta(3) and altering structure of tubulin-alpha. PMID: 18543212
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亞細胞定位：

Cytoplasm. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cleavage furrow. Midbody. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.
蛋白家族：

TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
組織特異性：

Widely expressed.
數據庫鏈接：

HGNC: 1717

OMIM: 603151

KEGG: hsa:989

STRING: 9606.ENSP00000381992

UniGene: Hs.191346

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