SENP7 Antibody

中文名稱：

SENP7兔多克隆抗體
貨號：

CSB-PA805340LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA805340LA01HU diluted at 1:500 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SENP7 Polyclonal antibody
Uniprot No.：

Q9BQF6
基因名：

SENP7
別名：

KIAA1707 antibody; Senp7 antibody; SENP7_HUMAN antibody; Sentrin specific protease antibody; Sentrin-specific protease 7 antibody; Sentrin/SUMO-specific protease SENP7 antibody; SSP2 antibody; SUMO 1 specific protease 2 antibody; SUMO specific protease antibody; SUMO-1-specific protease 2 antibody; SUMO1/sentrin specific peptidase 7 antibody; SUSP2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sentrin-specific protease 7 protein (128-366AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SENP7 Antibody (CSB-PA805340LA01HU)，的標記方式是Non-conjugated。對于SENP7 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA805340LB01HU	SENP7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA805340LC01HU	SENP7 Antibody, FITC conjugated
Biotin	CSB-PA805340LD01HU	SENP7 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Protease that deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms.
基因功能參考文獻：
1. SPOP inhibits hepatocellular carcinoma (HCC) cell metastasis via ubiquitin-dependent SENP7 proteolysis and may thus serve as a new opinion for the prevention of HCC metastasis. PMID: 29777712
2. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4 PMID: 25895136
3. deSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair. PMID: 24018422
4. differential splicing of the SENP7 regulates either tumor suppression or progression PMID: 23045645
5. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family. PMID: 21878624
6. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2 PMID: 18799455
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蛋白家族：

Peptidase C48 family
數據庫鏈接：

HGNC: 30402

OMIM: 612846

KEGG: hsa:57337

STRING: 9606.ENSP00000377655

UniGene: Hs.529551

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