SEMA3B Antibody
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中文名稱：SEMA3B兔多克隆抗體
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貨號：CSB-PA622646ESR2HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA622646ESR2HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SEMA3B Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：SEM3B_HUMAN antibody; Sema A(V) antibody; Sema V antibody; Sema3b antibody; Semaphorin V antibody; Semaphorin-3B antibody; Semaphorin-V antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Semaphorin-3B protein (570-749AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產品提供形式：Liquid
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應用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
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基因功能參考文獻：
- Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
- data provide new insights into the role of SEMA3B in mammary gland and provides a new branch of GATA3 signaling that is pivotal for inhibition of breast cancer progression and metastasis PMID: 28581515
- By upregulating p53 and p21 expression and inhibiting Akt (Ser473) phosphorylation, SEMA3B could induce cell cycle arrest at G1/S phase. PMID: 27349960
- As the clinical pathological glioma grade increased, SEMA3B expression decreased. PMID: 27050958
- Maternal SEMA 3B level increased in preeclampsia before the onset of manifestations, indicating that SEMA 3B plays a role in the pathogenesis of preeclampsia PMID: 26828533
- Aberrant expression and methylation of SEMA3B could be suggested as markers of lung and renal cancer progression. PMID: 25961819
- although plexin-A4 overexpression restored Sema3A signaling in plexin-A1-silenced cells, it failed to restore Sema3B signaling in plexin-A2-silenced cells. PMID: 25335892
- SEMA3B mRNA and protein is not altered in severe early onset preeclamptic placentas. PMID: 25454475
- CpG methylation of SEMA3B epigenetically regulates SEMA3B expression during development of gastric cancer. PMID: 24402303
- The transcriptional activity of RHOA, SEMA3B, and CKAP2 genes was assessed in blood samples of leukaemia patients and healthy donors. PMID: 24280143
- Three candidate tumor-suppressor genes, SEMA3B, AXUD1 and GNAT1 may be involved in oral squamous cell carcinoma. PMID: 23292452
- Loss of Sema3B expression is associated with biochemical recurrence of patients with low- and intermediate-risk prostate cancer. PMID: 23906303
- semaphorin-3B and semaphorin-3F have roles in ovarian cancer PMID: 20124444
- that methylation of promoter CpG-island contributed into inactivation of SEMA3B gene-suppressor in RCC. PMID: 20088387
- Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. PMID: 11809707
- SEMA3B gene alterations may play a important role in the malignant transformation of NSCLC via a two-hit mechanism, including epigenetic changes and allelic loss, for tumor suppressor gene inactivation. PMID: 12810670
- Heterozygous or homozygous variant genotype confers a >40% reduced relative risk of lung cancer in Latino Americans controlling for other lung cancer risk factors. PMID: 15831529
- Higher level of SEMA3B expression was found in differentiated tumors with favorable histopathology (n = 19) than in tumors with unfavorable histology. PMID: 17452250
- A putative role for SEMA3B as an osteoblast protein that regulates bone mass and skeletal homeostasis. PMID: 18356290
- SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion. PMID: 18458115
- Repulsion of human umbilical vascular endothelial cells by sema3B-m was mediated primarily by the neuropilin-1 receptor but sema3B-m was also able to transduce signals via neuropilin-2 PMID: 18757406
- SEMA3B is a potential tumor suppressor that induces apoptosis in SEMA3B-inactivated tumor cells through the Np-1 receptor by inactivating the Akt signaling pathway. PMID: 18922901
- IGFBP-6 is the effector of tumor suppressor activity of SEMA3B. PMID: 18985860
- SEMA3B plays role in inhibiting of growth of renal, ovarian and colorectal cancer cells. PMID: 19548530
- These data indicate that polymorphisms in SEMA3B are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men PMID: 19683737
- Identification of semaphorin 3B as a direct target of p53. PMID: 11922394
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亞細胞定位：Secreted. Endoplasmic reticulum. Note=Accumulates in the endoplasmic reticulum.
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蛋白家族：Semaphorin family
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組織特異性：Expressed abundantly but differentially in a variety of neural and nonneural tissues.
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數據庫鏈接：
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