SEL1L Antibody

中文名稱：

SEL1L兔多克隆抗體
貨號：

CSB-PA866208LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA866208LA01HU diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA866208LA01HU diluted at 1:100 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA866208LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SEL1L Polyclonal antibody
Uniprot No.：

Q9UBV2
基因名：

SEL1L
別名：

IBD2 antibody; PRO1063 antibody; Protein sel-1 homolog 1 antibody; SE1L1_HUMAN antibody; Sel 1 like protein antibody; Sel 1 suppressor of lin 12 like antibody; Sel-1L antibody; SEL1 LIKE antibody; Sel1l antibody; SEL1LIKE antibody; Suppressor of lin-12-like protein 1 antibody; TSA305 antibody; UNQ128 antibody; UNQ128/PRO1063 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein sel-1 homolog 1 protein (22-181AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SEL1L Antibody (CSB-PA866208LA01HU)，的標記方式是Non-conjugated。對于SEL1L Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA866208LB01HU	SEL1L Antibody, HRP conjugated	ELISA
FITC	CSB-PA866208LC01HU	SEL1L Antibody, FITC conjugated
Biotin	CSB-PA866208LD01HU	SEL1L Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
基因功能參考文獻：
1. In summary, ER retention of pathogenic VLDLR mutants involves binding to calnexin, elevated endoplasmic reticulum stress, and delayed degradation which is dependent on SEL1L. PMID: 29371607
2. Silencing of SEL1L during infection also stabilized an interaction of gO with the ER lectin OS-9, which likewise suggests that gO is an ER-associated degradation (ERAD) substrate. Taken together, our results identify an intriguing interaction of UL148 with the ERAD machinery and demonstrate that gO behaves as a constitutive ERAD substrate during infection. PMID: 29997207
3. Together, these results suggest that ER stress might comprise an important factor in GCD2 pathophysiology and that the effects of 4-PBA treatment might have important implications for the development of GCD2 therapeutics. PMID: 27373828
4. The SEL1L critically regulates HRD1-mediated disposal of misfolded cargo through its short membrane spanning stretch. PMID: 26471130
5. this is the first study reporting a significant association of the SEL1L SNP rs12435998 constitutive genetic variant with an improved overall survival in glioblastoma multiforme patients PMID: 25948789
6. Low expression of SEL1L is associated with pancreatic ductal adenocarcinoma. PMID: 23661430
7. Data revealed close interaction of these two proteins in regulating the cross-talk between extracellular matrix and insulin signalling to create a favourable micro-environment for ss-cell development and function. PMID: 24324549
8. SEL1L down-modulation synergy enhances valporic acid cytotoxic effects by influencing glioma stem cells proliferation and self-renewal properties. PMID: 24311781
9. ATF6 represents a novel type of ERAD-Lm substrate requiring SEL1L for degradation despite its transmembrane nature. PMID: 24043630
10. ERdj5, by binding to Sel1L, triggers BiP-Cholera toxin interaction proximal to the Hrd1 complex; postulate this scenario enables the Hrd1-associated retrotranslocation machinery to capture the toxin efficiently once the toxin is released from BiP PMID: 23363602
11. SEL1L expression is a potential colorectal cancer (CRC) tissue biomarker since its expression is significantly higher in adenoma cells with respect to normal mucosa; the levels of expression decrease in undifferentiated CRC cancers PMID: 22350780
12. the rs12435998 SNP in SEL1L gene plays a role in modifying age at diagnosis of PDA in Caucasian nonsmokers. PMID: 21656579
13. Two new SEL1L variants are engaged in endosomal trafficking and secretion via vesicles, which could contribute to relieve ER stress in tumorigenic cells. PMID: 21359144
14. regulation of the stability and assembly of the HRD1-SEL1L complex is critical to optimize the degradation kinetics of ERAD substrates PMID: 21454652
15. Overexpression of SEL1L protein is likely an early event during the pathogenesis of esophageal squamous cell carcinoma. PMID: 17822620
16. SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro. PMID: 11809711
17. Allele frequency of two intragenic microsatellite loci of SEL1L gene in Northern Italian population. PMID: 12030374
18. Notch signal transduction is not regulated by SEL1L in leukaemia and lymphoma cells in culture. PMID: 12553058
19. Region within SEL1L between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. PMID: 14729273
20. SEL1L has a very complex structure consisting of 21 exons featuring several alternative transcripts encoding for putative protein isoforms. Its complexity ensures protein flexibility and specificity. PMID: 16331677
21. SEL1L alters the expression of mediators involved in the remodeling of the extracellular matrix by creating a microenvironment that is unfavorable to invasive growth. PMID: 16331889
22. A possible role of the novel polymorphism as independent susceptibility factor of Alzheimer's dementia is shown PMID: 16412574
23. endoplasmic reticulum stress-induced HRD1 and SEL1 expressions are mediated by IRE1-XBP1- and ATF6-dependent pathways, respectively PMID: 17967421
24. OS-9 and GRP94 deliver mutant alpha1-antitrypsin to the Hrd1-SEL1L ubiquitin ligase complex for ERAD PMID: 18264092
25. These findings reveal a role for SEL1L and HRD1 in IgM quality control. PMID: 18314878
26. XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP PMID: 18502753
27. identified AUP1, UBXD8, UBC6e, and OS9 as functionally important components of this degradation complex formed by proteins that interact with SEL1L PMID: 18711132
28. knockdown of SEL1L [sel-1 suppressor of lin-12-like (Caenorhabditis elegans)], a member of an E3 ubiquitin ligase complex involved in ER protein extraction, rescued significant amounts of Cln6(G123D) and Cln6(M241T) polypeptides. PMID: 18811591
29. SEL1L-B and -C participate to novel molecular pathways that, in parallel with ERAD, contribute to the disposure of misfolded/unfolded or orphan proteins through degradation or secretion PMID: 19204006
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亞細胞定位：

Endoplasmic reticulum membrane; Single-pass type I membrane protein.
蛋白家族：

Sel-1 family
組織特異性：

Highly expressed in pancreas.
數據庫鏈接：

HGNC: 10717

OMIM: 602329

KEGG: hsa:6400

STRING: 9606.ENSP00000337053

UniGene: Hs.181300

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