SCNN1D Antibody

說明書

中文名稱：

SCNN1D兔多克隆抗體
貨號(hào)：

CSB-PA040298
規(guī)格：

￥1090
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

Uniprot No.：

P51172
基因名：

SCNN1D
別名：

Amiloride sensitive sodium channel subunit delta antibody; Amiloride-sensitive sodium channel subunit delta antibody; Delta ENaC antibody; Delta NaCH antibody; Delta-ENaC antibody; Delta-NaCH antibody; DNACH antibody; ENaC Delta antibody; ENaCD antibody; ENaCdelta antibody; Epithelial Na(+) channel subunit delta antibody; MGC149710 antibody; MGC149711 antibody; Nonvoltage gated sodium channel 1 subunit delta antibody; Nonvoltage-gated sodium channel 1 subunit delta antibody; SCNED antibody; SCNN1D antibody; SCNND_HUMAN antibody; Sodium channel, nonvoltage gated 1, delta antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the Internal region of Human ENaCδ.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

WB, IF, ELISA

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IF	1:200-1:1000
ELISA	1:20000

Protocols：

Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
基因功能參考文獻(xiàn)：
1. delta-ENaC expression is low in NCI-H441, Calu-3, and ATI cells and does not contribute to transepithelial sodium absorption PMID: 25677639
2. study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins PMID: 22505667
3. delta-ENaC undergoes dynamin-independent endocytosis as opposed to alphabetagamma-channels. PMID: 22159085
4. These results suggest that COMMD1 downregulates deltaENaC activity by reducing deltaENaC surface expression through promoting internalization of surface deltaENaC to an intracellular recycling pool, possibly via enhanced ubiquitination. PMID: 21741370
5. Cpt-cAMP activates human epithelial sodium channels via relieving self-inhibition. PMID: 21419751
6. CPT-cGMP Stimulates Human Alveolar Fluid Clearance by Releasing External Na+ Self-Inhibition of ENaC. PMID: 21562313
7. Data support a physiological role for SGK1.1 in the regulation of delta-ENaC through a pathway that differs from the classical one and suggest that the kinase could serve as an integrator of different signaling pathways converging on the channel. PMID: 20631247
8. delta ENaC is regulated by Murr1 PMID: 14645214
9. ENaCdelta activity is regulated by protons, and may contribute to the pH sensation and/or pH regulation in the human brain PMID: 14726523
10. ENaCdelta is chemically activated by capsazepine by a proton-dependent mechanism PMID: 15308635
11. analysis of anovel spliced variant of the ENaC delta-subunit in the human brain PMID: 16930535
12. ENaC delta isoforms are widely expressed in pyramidal cells of the human and monkey cerebral cortex and in different neuronal populations of telencephalic subcortical nuclei. PMID: 17472699
13. Expression analyses at the level of mRNA clearly revealed that ENaC delta transcript was strongly expressed in human melanoma cells using reverse transcription-polymerase chain reaction and cell-based in situ hybridization techniques. PMID: 18073141
14. ENaCdelta is a candidate molecule for pH sensing in the gastrointestinal system in humans, providing a novel therapeutic target for gastro-oesophageal reflux disease PMID: 18951889
15. the delta-subunit of ENaC alters proteolytic channel activation and enhances base-line channel activity PMID: 19717556
16. delta ENaC is a proton sensor PMID: 15084585
顯示更多

收起更多
亞細(xì)胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1D subfamily
數(shù)據(jù)庫鏈接：

HGNC: 10601

OMIM: 601328

KEGG: hsa:6339

STRING: 9606.ENSP00000368411

UniGene: Hs.512681

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XPNPEP1 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human
VDR Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human