SCN4B Antibody

中文名稱：

SCN4B兔多克隆抗體
貨號：

CSB-PA818246LA01HU
規(guī)格：

￥440
圖片：
Immunofluorescence staining of HepG2 cells with CSB-PA818246LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) SCN4B Polyclonal antibody
Uniprot No.：

Q8IWT1
基因名：

SCN4B
別名：

SCN4B antibody; Sodium channel subunit beta-4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sodium channel subunit beta-4 protein (31-162AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產(chǎn)品，SCN4B Antibody (CSB-PA818246LA01HU)，的標記方式是Non-conjugated。對于SCN4B Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產(chǎn)品名稱	應用
HRP	CSB-PA818246LB01HU	SCN4B Antibody, HRP conjugated	ELISA
FITC	CSB-PA818246LC01HU	SCN4B Antibody, FITC conjugated
Biotin	CSB-PA818246LD01HU	SCN4B Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
基因功能參考文獻：
1. SCN4B overexpression reduces cancer cell invasiveness and tumour progression. PMID: 27917859
2. Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer. PMID: 29723302
3. Data suggest that extracellular domains of SCN4B directly interact with each other in parallel homodimers that involve an intermolecular disulfide bond between unpaired Cys residues (Cys58) in loop connecting strands B and C and intermolecular hydrophobic and hydrogen-bonding interactions of N-terminal segments (Ser30-Val35); SCN4B homodimers appear to play role in cell-cell adhesion. PMID: 28655765
4. The expression of a human-specific isoform of the voltage-gated sodium channel subunit SCN4B was significantly correlated to lifetime alcohol consumption PMID: 25450227
5. results suggest the presence of a docking site that is maintained by a cysteine bridge buried within the hydrophobic core of beta4. PMID: 24297919
6. this is the first study to demonstrate an association of SCN4B mutations with AF, suggesting SCN4B as a novel AF susceptibility gene. PMID: 23604097
7. SCN5A-SCN4B were found to be essential for positive selection of CD4(+) T cells. PMID: 22842345
8. The researchers found evidence of an association between SCN4B subunit mutations and sudden infant death syndrome pathogenesis. PMID: 20226894
9. The paroxysmal extreme pain disorder associated Nav1.7 missense mutations M1627K, T1464I and V1299F increase Navbeta4 peptide-mediated resurgent sodium currents, in contrast to the erythromelalgia associated I848T and L858H Nav1.7 missense mutations. PMID: 21115638
10. molecular cloning and characterization of sodium channel beta4 PMID: 12930796
11. SCN4B is a long QT syndrome susceptibility gene. PMID: 17592081
12. Co-expression of the beta1 subunit impeded slow inactivation elicited by a 30-s depolarization, such that the voltage dependence was right shifted (depolarized) and recovery was hastened. PMID: 18941776
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相關疾病：

Long QT syndrome 10 (LQT10); Atrial fibrillation, familial, 17 (ATFB17)
亞細胞定位：

Cell membrane; Single-pass type I membrane protein.
蛋白家族：

Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
組織特異性：

Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
數(shù)據(jù)庫鏈接：

HGNC: 10592

OMIM: 608256

KEGG: hsa:6330

STRING: 9606.ENSP00000322460

UniGene: Hs.65239

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