SCN2B Antibody
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中文名稱：SCN2B兔多克隆抗體
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貨號：CSB-PA020838ESR1HU
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規(guī)格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA020838ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) SCN2B Polyclonal antibody
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Uniprot No.：
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基因名：SCN2B
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別名：SCN2B; UNQ326/PRO386; Sodium channel subunit beta-2
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Sodium channel subunit beta-2 protein (30-160AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier.
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基因功能參考文獻：
- Findings add to the understanding of beta2 role in Nav 1.5 trafficking and localisation, which must influence cell excitability and electrical coupling in the heart. PMID: 28597987
- The authors identified a flexible loop formed by (72)Cys and (75)Cys, a unique feature among the four beta-subunit isoforms. PMID: 26894959
- With increased beta-2 expression, prostate cancer cells display a trend of enhanced association with nerve axons. PMID: 24892658
- SCN2B is a new candidate gene associated with Brugada syndrome. PMID: 23559163
- beta2 is a PS/gamma-secretase substrate, gamma-secretase mediated cleavage of beta2-C-terminal fragment is required for cell-cell adhesion and migration of beta2-expressing cells PMID: 15833746
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相關(guān)疾病：Atrial fibrillation, familial, 14 (ATFB14)
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亞細胞定位：Membrane; Single-pass type I membrane protein.
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蛋白家族：Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
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組織特異性：Brain specific.
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數(shù)據(jù)庫鏈接：
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