SCARA5 Antibody

說(shuō)明書(shū)

中文名稱(chēng)：

SCARA5兔多克隆抗體
貨號(hào)：

CSB-PA020766LA01HU
規(guī)格：

￥440
圖片：
IHC image of CSB-PA020766LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of HepG2 cells with CSB-PA020766LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) SCARA5 Polyclonal antibody
Uniprot No.：

Q6ZMJ2
基因名：

SCARA5
別名：

FLJ23907 antibody; MGC45780 antibody; NET33 antibody; SCAR5_HUMAN antibody; SCARA 5 antibody; scara5 antibody; Scavenger receptor class A member 5 antibody; Scavenger receptor class A; member 5 (putative) antibody; Scavenger receptor class A; member 5 antibody; Scavenger receptor hlg antibody; Tesr antibody; Testis expressed scavenger receptor antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Scavenger receptor class A member 5 protein (303-428AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，SCARA5 Antibody (CSB-PA020766LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于SCARA5 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱(chēng)	應(yīng)用
HRP	CSB-PA020766LB01HU	SCARA5 Antibody, HRP conjugated	ELISA
FITC	CSB-PA020766LC01HU	SCARA5 Antibody, FITC conjugated
Biotin	CSB-PA020766LD01HU	SCARA5 Antibody, Biotin conjugated	ELISA

克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1).
基因功能參考文獻(xiàn)：
1. our data provide a novel evidence for the biological and clinical significance of SPAG5 as a potential biomarker, and we demonstrate that SPAG5-b-catenin-SCARA5 might be a novel pathway involved in hepatocellular carcinoma progression. PMID: 30249289
2. SCARA5 may play an important role in tumorigenesis of breast cancer via promoter methylation PMID: 29908284
3. The present results provide the first evidence that SCARA5 inhibits lymphangiogenesis by downregulating VEGF-C, thereby inhibiting breast cancer lymphatic metastasis. PMID: 28497372
4. Knockdown of CSN5 increased SCARA5 expression and inhibited the proliferation and metastasis of HCC cells in vitro and in vivo. Finally, it was found that CSN5 regulated SCARA5 expression by modulating beta-catenin. PMID: 29189991
5. The methylation status of SCARA5 gene are abnormal in Hepatocellular Carcinoma patients, which may further be used as molecular markers for early diagnosis of Liver cancer. PMID: 29019900
6. Taken together, these results suggest that this newly identified Rock2-beta-catenin/TCF4-SCARA5 axis will provide novel insight into the understanding of the regulatory mechanisms of proliferation in human RCC. PMID: 27793664
7. SCARA5 and SBSN shown to have modest effects on cell proliferation or collagen gel contraction and maybe associated with peripheral vein graft patency. PMID: 25935274
8. this study demonstrated that knockdown of SCARA5 inhibits PDGFBBinduced HASMC proliferation and migration through suppression of the PDGF signaling pathway. PMID: 27035566
9. The overexpression of SCARA5 significantly inhibited the proliferation, colony formation and migration/invasion abilities of osteosarcoma cells. PMID: 26847210
10. Scara5 was downregulated, pointing out this receptor as a potential player implicated in retinopathy and also as a possible therapeutic target. PMID: 25259650
11. Results demonstrate the involvement of SCARA3 and SCARA5 in the uptake of PF14-oligonucleotide nanocomplexes. PMID: 22138034
12. Data show that decidualization was associated with increased expression of 428 genes including SCARA5 (181-fold), DKK1 (71-fold) and PROK1 (32-fold), and decreased expression of 230 genes including MMP-7 (35-fold) and SFRP4 (21-fold). PMID: 21858178
13. Observational study of gene-disease association. (HuGE Navigator) PMID: 21029358
14. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
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亞細(xì)胞定位：

Cell membrane; Single-pass type II membrane protein.
蛋白家族：

SCARA5 family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 28701

OMIM: 611306

KEGG: hsa:286133

STRING: 9606.ENSP00000346990

UniGene: Hs.591833

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