SAT2 Antibody

中文名稱：

SAT2兔多克隆抗體
貨號：

CSB-PA836208LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA836208LA01HU diluted at 1:400 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA836208LA01HU diluted at 1:400 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunofluorescence staining of MCF-7 cells with CSB-PA836208LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SAT2 Polyclonal antibody
Uniprot No.：

Q96F10
基因名：

SAT2
別名：

Amino acid transporter A2 antibody; ATA2 antibody; Diamine acetyltransferase 2 antibody; Diamine N acetyltransferase 2 antibody; Polyamine N acetyltransferase antibody; Polyamine N-acetyltransferase 2 antibody; Protein 40 9 1 antibody; SAT2 antibody; SAT2_HUMAN antibody; SNAT2 antibody; Solute carrier family 38 member 2 antibody; Spermidine/spermine N(1)-acetyltransferase 2 antibody; Spermidine/spermine N1 acetyltransferase 2 antibody; Spermidine/spermine N1 acetyltransferase family member 2 antibody; SSAT2 antibody; System A amino acid transporter 2 antibody; System A transporter 1 antibody; System N amino acid transporter 2 antibody; Thialysine N-epsilon-acetyltransferase antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Diamine acetyltransferase 2 protein (1-170AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，SAT2 Antibody (CSB-PA836208LA01HU)，的標記方式是Non-conjugated。對于SAT2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA836208LB01HU	SAT2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA836208LC01HU	SAT2 Antibody, FITC conjugated
Biotin	CSB-PA836208LD01HU	SAT2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the N-acetylation of the amino acid thialysine (S-(2-aminoethyl)-L-cysteine), a L-lysine analog with the 4-methylene group substituted with a sulfur. May also catalyze acetylation of polyamines, such as norspermidine, spermidine or spermine. However, ability to acetylate polyamines is weak, suggesting that it does not act as a diamine acetyltransferase in vivo.
基因功能參考文獻：
1. Crystallization of this protein and its recombinant form and its complexation with coenzyme A. PMID: 16596569
2. The expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated. PMID: 17119850
3. SSAT2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha PMID: 17558023
4. SSAT1, which shares 46% amino acid identity with SSAT2, also binds to HIF-1alpha and promotes its ubiquitination/degradation. However, in contrast to SSAT2, SSAT1 acts by stabilizing the interaction of HIF-1alpha with RACK1 PMID: 17875644
5. expression of SSAT mediated by Ad-SSAT infection inhibits the growth of colorectal cancer cells PMID: 18949426
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亞細胞定位：

Cytoplasm.
蛋白家族：

Acetyltransferase family
組織特異性：

Widely expressed. Under physiological conditions, SSAT2 is expressed at lower level that SSAT1 (SSAT). Many tissues express only SSAT1, several tissues express both SSAT1 and SSAT2, and bone, cervix, ovary and pineal gland expressed only SSAT2.
數據庫鏈接：

HGNC: 23160

OMIM: 611463

KEGG: hsa:112483

STRING: 9606.ENSP00000269298

UniGene: Hs.10846

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