SASH1 Antibody, Biotin conjugated
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中文名稱：SASH1兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA020714LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) SASH1 Polyclonal antibody
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Uniprot No.：
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基因名：SASH1
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別名：2500002E12Rik antibody; dJ323M4 antibody; dJ323M4.1 antibody; KIAA0790 antibody; PEPE 1 antibody; PEPE1 antibody; Proline glutamate repeat containing protein antibody; Proline-glutamate repeat-containing protein antibody; RP3 323M4.1 antibody; SAM and SH3 domain containing 1 antibody; SAM and SH3 domain containing protein 1 antibody; SAM and SH3 domain-containing protein 1 antibody; SASH 1 antibody; Sash1 antibody; SASH1_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human SAM and SH3 domain-containing protein 1 protein (76-191AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis.
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基因功能參考文獻：
- findings suggested that SASH1 can be useful as a new prognostic marker and therapeutic target in cervical cancer patients. PMID: 28975991
- Data show that SAM and SH3 domain containing 1 protein (SASH1) binds with mitogen-activated protein kinase kinase 2 (MAP2K2), and SASH1 mutations promote binding between SASH1 and MAP2K2. PMID: 28382689
- SASH1 is prognostic in breast cancer and could have subtype-dependent effects on breast cancer progression. PMID: 27637080
- SASH1 may inhibit hepatocarcinoma cell invasion and metastasis through down-regulating the Shh-Gli1 and PI3K-AKT pathways PMID: 28600143
- Case Report: SASH1 missense mutation in a Chinese Family with multiple lentigines. PMID: 27840890
- SASH1 acts through NOTCH1 and its inhibitor DLK1 in a three-dimensional model of lumenogenesis involving CEACAM1. PMID: 28823832
- SASH1 is cleaved by caspase-3 following Ultraviolet C-induced apoptosis. PMID: 27831555
- a novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype. PMID: 27885802
- Overexpression of SASH1 inhibits TGF-beta1-induced EMT. PMID: 27178818
- Overexpression of SASH1 suppressed the expression of Shh. PMID: 27178819
- The loss or inhibition of SASH1 expression may play an important role in thyroid cancer development, invasion, and metastasis. PMID: 26722413
- Two SNPs were significantly associated with rotator cuff tearing, residing in SAP30BP on chromosome 17 and SASH1 on chromosome 6. PMID: 26350878
- SASH1 expression is increased in atherosclerotic carotids in smokers and its silencing affects endothelial angiogenic functions PMID: 26318107
- SASH1 expression strongly correlated with glioma grades, showing higher expression at a lower grade. PMID: 26424902
- Data suggest that SASH1 (SAM and SH3 domain-containing protein 1) should be added to the list of genes responsible for autosomal-dominant and -recessive genodermatosis. PMID: 25315659
- SASH1 Is Involved in an Autosomal Dominant Lentiginous Phenotype. PMID: 26203640
- Propose that increase of DNA methylation level in the promoter region of gene SASH1, particularly CpG_26.27 or CpG_54.55 sites, possibly repressed SASH1 expression in breast cancer. PMID: 24344014
- The SASH1 gene is blocked cyclin B1-Cdc2 binding, either directly or indirectly, leading to G2/M arrest. PMID: 23023727
- SASH1 regulates IQGAP1-E-Cadherin signalling and crosstalking between GPCR signalling, calmodulin signalling for the modulation of melanocytes invasion. PMID: 23333244
- Overexpression of SASH1 might be associated with the inhibition of growth, proliferation, and invasion osteosarcoma cells. PMID: 23108792
- Loss of SASH1 is associated with glioma. PMID: 22915266
- The SASH1 gene may inhibit A549 cell growth and proliferation as well as promote cellular apoptosis. The overexpression of the SASH1 gene may also be related to the decreased migration of A549 human lung cancer cells. PMID: 22488244
- A mechanistic role for SASH1 in tumor formation by regulating the adhesive and migratory behavior of cancer cells has been shown. PMID: 21820526
- tumor suppressor gene possibly involved in tumorigenesis of breast and other solid cancers PMID: 12771949
- Downregulated expression of the candidate tumour suppressor gene SASH1 is associated with colon cancer PMID: 17088907
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亞細胞定位：Cytoplasm.
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組織特異性：Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes,
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