SAR1A Antibody

說明書

中文名稱：

SAR1A兔多克隆抗體
貨號：

CSB-PA020702GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NR31
基因名：

SAR1A
別名：

COPII associated small GTPase antibody; COPII-associated small GTPase antibody; GTP binding protein SAR1a antibody; GTP-binding protein SAR1a antibody; Masra 2 antibody; Masra2 antibody; SAR 1 antibody; SAR1 gene homolog A antibody; SAR1 homolog A (S. cerevisiae) antibody; SAR1A antibody; SAR1a gene homolog (S cerevisiae) 1 antibody; SAR1a gene homolog 1 (S cerevisiae) antibody; SAR1a gene homolog 1 antibody; SAR1A_HUMAN antibody; SARA 1 antibody; Sara antibody; SARA1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SAR1A
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).
基因功能參考文獻：
1. Study data suggest that SAR1A and SAR1B are the critical regulators of trafficking of Nav1.5. Moreover, SAR1A and SAR1B interact with MOG1, and are required for MOG1-mediated cell surface expression and function of Nav1.5. PMID: 30251687
2. Study shows that the bona fide nonglycoprotein Nox5, a transmembrane superoxide-producing NADPH oxidase, is transported to the cell surface in a manner resistant to co-expression of Sar1 (H79G), a GTP-fixed mutant of the small GTPase Sar1, which blocks COPII vesicle fission from the endoplasmic reticulum. PMID: 29718541
3. No associations were observed between any of the secretion associated Ras related GTPase 1A (SAR1a) promoter variants and baseline fetal hemoglobin HbF among sickle cell disease (SCD) patients. PMID: 28499394
4. Sar1 is a novel regulator of endoplasmic reticulum-mitochondrial contact sites in the metazoans. PMID: 27101143
5. SAR1A gene silencing in hepatocytes mimics the effect of ethanol: dedimerization of giantin, arresting PDIA3 in the endoplasmic reticulum (ER) and large-scale alterations in Golgi architecture. PMID: 26607390
6. Data indicate that hydroxyurea (HU) induces SAR1 protein expression, which in turn activates gamma-globin expression, predominantly through the Gialpha/JNK/Jun pathway. PMID: 24914133
7. although Sar1A antagonizes the lipoprotein secretion-promoting activity of Sar1B, both isoforms modulate the expression of genes encoding cholesterol biosynthetic enzymes and the synthesis of cholesterol de novo. PMID: 24338480
8. Sar1 mutant proteins added to metaphase-arrested Xenopus laevis egg extracts cause dramatic effects on membrane organization. PMID: 22605651
9. the behavior of the human of Sar1A and Sar1B, a key component of the COPII family of vesicle coat proteins, was examined. PMID: 22974979
10. Sedlin bound and promoted efficient cycling of Sar1, a guanosine triphosphatase that can constrict membranes, and thus allowed nascent carriers to grow and incorporate procollagen prefibrils. PMID: 23019651
11. lipid-directed and tether-assisted Sar1 organization controls membrane constriction to regulate ER export. PMID: 20624903
12. the intracellular trafficking of hCaR from the endoplasmic reticulum is Sar1-dependent via coat protein complex-II vesicles. PMID: 20457124
13. The Sec31 fragment stimulates GAP activity of Sec23/24, and a convergence of Sec31 and Sec23 residues at the Sar1 GTPase active site explains how GTP hydrolysis is triggered leading to COPII coat disassembly. PMID: 17981133
14. Sar 1 H79G mutants efficiently blocked the plasma membrane trafficking of the Kir3.1/Kir3.4 complex however they did not block the Gbeta1gamma2/Kir3.1 interaction. PMID: 19135528
15. Kir6.2 contains a di-acidic endoplasmic reticulum exit signal, which promotes endoplasmic reticulum exit via a process that requires Sar1. PMID: 19357197
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亞細胞定位：

Endoplasmic reticulum. Golgi apparatus.
蛋白家族：

Small GTPase superfamily, SAR1 family
數據庫鏈接：

HGNC: 10534

OMIM: 607691

KEGG: hsa:56681

STRING: 9606.ENSP00000362335

UniGene: Hs.499960

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