SAMD9 Antibody

說明書

中文名稱：

SAMD9兔多克隆抗體
貨號：

CSB-PA775725
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA775725(SAMD9 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q5K651
基因名：

SAMD9
別名：

C7orf5 antibody; DRIF1 antibody; expressed in aggressive fibromatosis antibody; KIAA2004 antibody; NFTC antibody; OEF1 antibody; OEF2 antibody; SAM domain-containing protein 9 antibody; SAMD9 antibody; SAMD9_HUMAN antibody; sterile alpha motif domain containing 9 antibody; Sterile alpha motif domain-containing protein 9 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Synthetic peptide of Human SAMD9
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May play a role in the inflammatory response to tissue injury and the control of extra-osseous calcification, acting as a downstream target of TNF-alpha signaling. Involved in the regulation of EGR1, in coordination with RGL2. May be involved in endosome fusion.
基因功能參考文獻：
1. In humans, both SAMD9 and SAMD9L are poxvirus restriction factors, although the latter requires interferon induction in many cell types. PMID: 29447249
2. findings establish SAMD9/SAMD9L mutations as a new class of germline lesions with variable clinical phenotypes, including familial MDS PMID: 28487541
3. Progressive loss of mutated SAMD9 through the development of monosomy 7 (-7), deletions of 7q (7q-), and secondary somatic loss-of-function (nonsense and frameshift) mutations in SAMD9 rescued the growth-restricting effects of mutant SAMD9 proteins in bone marrow and was associated with increased length of survival. PMID: 28346228
4. SAMD9 mutation is associated with MIRAGE syndrome. PMID: 27182967
5. Replication of the K1L(-)C7L(-) mutant vaccinia virus virus was enabled by multiple siRNAs to SAMD9 or WDR6. PMID: 26242627
6. SAMD9 is down-regulated in non-small cell lung cancer. Knockdown of SAMD9 expression increased the invasion, migration and proliferation in H1299 cells in vitro and overexpression of SAMD9 suppressed proliferation and invasion in A549 cells. PMID: 25450373
7. When SAMD9 is stimulated due to failure of the viral antagonism during infection, the resulting antiviral granules exhibit properties different from those of the canonical stress granules. PMID: 25428864
8. Over-expression of SAMD9 is correlated with the metastasis of esophageal squamous cell carcinoma PMID: 24721411
9. M062 also binds and antagonizes cellular SAMD9 in human cells, suggesting that SAMD9 is a novel innate antiviral factor against poxviruses. PMID: 21248034
10. SAMD9, an IFN-gamma-responsive protein, interacts with RGL2 to diminish the expression of EGR1, a protein of direct relevance to the pathogenesis of ectopic calcification and inflammation. PMID: 21160498
11. SAMD9 could be a key molecule to control cancer cell death by inactivated Sendai virus particle or IFN-beta treatment. PMID: 19830690
12. Mutation analysis revealed a homozygous mutation in the SAMD9 gene (K1495E), which was found to segregate with the disease in all families and to interfere with the protein expression. PMID: 16960814
13. SAMD9 and SAMD9L are a novel family of genes, which play a role regulating cell proliferation and suppressing the neoplastic phenotype; the human gene exists in rat, but is lost in mouse, due to a mouse specific rearrangement PMID: 17407603
14. PIvotal role in calcification and thus implicated in various hereditary diseases such as atherosclerosis, calcinosis and autoimmune diseases. PMID: 17507861
15. SAMD9 may have a role in the TNF-alpha signaling pathway and in the regulation of extra-osseous calcification PMID: 18094730
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相關疾病：

Tumoral calcinosis, normophosphatemic, familial (NFTC); MIRAGE syndrome (MIRAGE)
亞細胞定位：

Cytoplasm.
組織特異性：

Widely expressed. Very low levels are detected in skeletal muscle. Not detected in brain. Down-regulated in aggressive fibromatosis, as well as in breast and colon cancers. Up-regulated in fibroblasts from patients with normophosphatemic tumoral calcinosi
數據庫鏈接：

HGNC: 1348

OMIM: 610455

KEGG: hsa:54809

STRING: 9606.ENSP00000369292

UniGene: Hs.65641

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