RRP8 Antibody
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中文名稱：RRP8兔多克隆抗體
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貨號：CSB-PA008360
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規格：￥1090
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圖片：
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Western Blot analysis of MCF-7 cells using Cerebral 1 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：RRP8
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別名：Cerebral protein 1 antibody; hypothetical protein LOC23378 antibody; KIAA0409 antibody; NML antibody; Nucleomethylin antibody; Ribosomal RNA processing 8 methyltransferase homolog antibody; Ribosomal RNA processing 8, methyltransferase, homolog (yeast) antibody; Ribosomal RNA processing protein 8 antibody; Ribosomal RNA-processing protein 8 antibody; RRP 8 antibody; RRP8 antibody; RRP8 methyltransferase homolog antibody; RRP8_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthesized peptide derived from the Internal region of Human Cerebral 1.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, IHC, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
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基因功能參考文獻：
- NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11-MDM2 complex, which activates the p53 pathway. PMID: 27149924
- Breast tumors without detectable nucleolar NML expression had poor survival. PMID: 26505814
- Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively. PMID: 26098692
- Data indicate that the the nucleomethylin (NML)-SirT1 interaction was competitively inhibited by rRNA. PMID: 23897426
- These observations suggest that NML may regulate consumption of hepatic triglyceride in liver regeneration after partial hepatectomy due to storage of excess ATP. PMID: 19819226
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亞細胞定位：Nucleus, nucleolus. Note=Localizes at rDNA locus.
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蛋白家族：Methyltransferase superfamily, RRP8 family
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數據庫鏈接：
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