RREB1 Antibody
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中文名稱：RREB1兔多克隆抗體
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貨號：CSB-PA584591
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規格：￥2024
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圖片：
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using RREB1 antibody.
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) RREB1 Polyclonal antibody
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Uniprot No.：
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基因名：RREB1
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Synthesized peptide derived from internal of Human RREB1.
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免疫原種屬：Homo sapiens (Human)
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克隆類型：Polyclonal
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution IHC 1:50-1:100 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Transcription factor that binds specifically to the RAS-responsive elements (RRE) of gene promoters. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1. Promotes brown adipocyte differentiation. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression.
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基因功能參考文獻：
- Of the 465,447 CpG sites analyzed, 12 showed differential methylation (false discovery rate <0.15), including markers within genes associated with monogenic diabetes (HNF4A) or obesity (RREB1). The overall methylation at HNF4A showed inverse correlations with mRNA expression levels, though non significant PMID: 29099273
- RREB1 cooperates with noncoding RNA linc-ADAMTS5 to inhibit ADAMTS5 expression, thereby affecting degeneration of the extracellular matrix (ECM) of the intervertebral disc. PMID: 28341660
- RREB1 and CCND1 gains are common in nail apparatus melanoma PMID: 27185405
- Histone modifier genes (JMJD1C, RREB1, MINA, KDM7A) alter conotruncal heart phenotypes in 22q11.2 deletion syndrome. PMID: 26608785
- RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease. PMID: 25027322
- The pathway of RREB1/ZIP3/Zinc and its downregulation during oncogenesis exist to prevent the accumulation of cytotoxic levels of zinc during the development and progression of the malignant cells in pancreatic adenocarcinoma. PMID: 25050557
- RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. PMID: 21360563
- Thus HNT and c are functional homologs at the level of DNA binding, transcriptional regulation and developmental control PMID: 24418439
- Data show the transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level. PMID: 24348900
- RREB1 is overexpressed in colorectal adenocarcinoma tumors. RREB1 repressed miR-143/145 modulates KRAS signaling. PMID: 22751122
- These results support a concept that downregulation of RREB-1 causes downregulation of ZIP3, which results in decreased zinc in pancreatic premalignant and carcinoma cells PMID: 22427155
- Data indicate the upregulation of RREB1, PDE6B, and CD209 suggests that these proteins might play important roles in the differentiation of primitive gut tube cells from embryonic stem cells (hESCs) and in primitive gut tube development into pancreas. PMID: 21792086
- Data show that the combination of concurrent zinc, ZIP3, and RREB-1 changes represent early events in the development of adenocarcinoma. PMID: 21613827
- RREB1 transcription factor splice variants are associated with urologic cancer. PMID: 21703425
- KRAS and RREB1 are targets of miR-143/miR-145, revealing a feed-forward mechanism that potentiates Ras signaling PMID: 21159816
- Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. PMID: 19802870
- The p16 promoter can be downregulated by transfected human RREB, in a Ras- or Mek-dependent manner, and that the BALB/c promoter is more sensitive than DBA/2 to regulation by RREB, a ras-responsive transcriptional element with zinc-finger binding motifs. PMID: 12700664
- Finb functions as a sequence-specific transcriptional repressor of the hANG gene PMID: 15067362
- essential to reduce cell-cell adhesion when epithelial cells within an interconnected group undergo dynamic changes in cell shape PMID: 18394891
- Findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage. PMID: 19558368
- This demonstration is the first of a repressor factor of HLA-G transcriptional activity taking part in HLA-G repression by epigenetic mechanisms. PMID: 19890057
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亞細胞定位：Nucleus speckle.
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蛋白家族：Krueppel C2H2-type zinc-finger protein family
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組織特異性：Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain.
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數據庫鏈接：
