RRAS Antibody

說明書

中文名稱：

RRAS兔多克隆抗體
貨號：

CSB-PA663638
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA663638(RRAS Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)

Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human chromaffin cell tumor tissue, NIH/3T3 cells, Primary antibody: CSB-PA663638(RRAS Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P10301
基因名：

RRAS
別名：

Oncogene RRAS antibody; p23 antibody; R Ras antibody; Ras related Protein antibody; Ras related protein R Ras antibody; Ras-related protein R-Ras antibody; related RAS viral (r ras) oncogene homolog antibody; RRAS antibody; RRAS_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human RRAS
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:1000-1:2000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulates the organization of the actin cytoskeleton. With OSPBL3, modulates integrin beta-1 (ITGB1) activity.
基因功能參考文獻：
1. R-Ras activation is associated melanoma tumorigenesis. PMID: 26993606
2. this study identified potential biochemical players involved in distant recurrence and indicates that R-Ras and Transgelin are potential post-surgical prognostic biomarkers for Stage III colorectal cancer PMID: 27270312
3. RRAS is a key regulator of miR-34/449 promotion of actin network formation during multiciliogenesis. PMID: 26381333
4. Evidence is provided of a functional link between RRAS and MAPK signalling and reveal an unpredicted role of enhanced RRAS function in human disease. PMID: 24705357
5. Girdin regulates the trafficking of VE-cadherin in synergy with R-Ras. PMID: 25869066
6. phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. PMID: 25447204
7. Contradicting the positive association reported in previous studies, our results indicate that R-Ras activation may negatively regulate the transformation of breast epithelial cells. PMID: 24700169
8. A polymorphism linked to RRAS, SCAF1, IRF3 and BCL2L12 genes is associated with cirrhosis in hepatitis C virus carriers. PMID: 24131527
9. Patients with gemistocytic astrocytomas with an RRAS deletion tend to have shorter survival rates than those without deletion. PMID: 25192052
10. These data suggest that pharmacological inhibition of RRAS signaling may confer therapeutic benefit in Huntington's disease. PMID: 23209424
11. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization. PMID: 22897853
12. Maintaining endothelial barrier function is dependent upon active R-Ras and association between R-Ras and FLNa. PMID: 21660952
13. Data suggest that the RRAS gene is an important regulatory module in the pathogenesis of biliary atresia (BA), which may serve as a novel prognostic marker for BA. PMID: 21390152
14. data support a model in which R-Ras functionally associates with FLNa and thereby regulates integrin-dependent migration PMID: 20585650
15. Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. PMID: 20385769
16. study of the potential contribution in generating of estrogen-independence in MCF-7 cells PMID: 12386818
17. the oncogene R-Ras promotes tumor growth of cervical epithelial cells and increases their migration potential over collagen through a pathway that involves PI 3-K. PMID: 12548599
18. activation of R-Ras promotes the formation of focal adhesions and a spread cell shape PMID: 12890755
19. Plexin-B1 mediates Sema4D-induced repulsive axon guidance signaling by acting as a GTPase activating protein for R-Ras PMID: 15297673
20. R-Ras plays a key role in cell migration by locally regulating the switch from Rac to Rho activity after membrane protrusion and adhesion PMID: 15525681
21. GPCRs rapidly activate R-Ras; R-Ras activation by the GPCRs is apparently directly induced by cyclic AMP-regulated Epac proteins; and activated R-Ras specifically controls GPCR-mediated phospholipase D stimulation PMID: 16754664
22. These findings show that R-Ras activity mediates inhibition of insulin signaling associated with suppression of estrogen action, implicating this GTPase in a growth-inhibitory mechanism associated with antiestrogen treatment of breast cancer. PMID: 16914723
23. R-Ras and ILK have roles upstream of GSK-3beta in the regulation of neuronal polarity PMID: 17107957
24. Notch1 ligand, Delta-like ligand-4, stimulates R-Ras-dependent alpha 5 beta 1 integrin-mediated adhesion, demonstrating the physiological relevance of this pathway. PMID: 17664272
25. results map the functional elements in the R-ras promoter sequence and suggest that the GABP may be critical for transcription of R-ras and for maintenance of normal blood vessel functions through the regulation of this gene PMID: 19011236
26. TCF8 activates R-Ras, another class of angiogenic regulator, to suppress angiogenesis by a mechanism other than a transcriptional attenuator. PMID: 19116136
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亞細胞定位：

Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS).
蛋白家族：

Small GTPase superfamily, Ras family
數據庫鏈接：

HGNC: 10447

OMIM: 165090

KEGG: hsa:6237

STRING: 9606.ENSP00000246792

UniGene: Hs.515536

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