RRAD Antibody
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中文名稱：RRAD兔多克隆抗體
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貨號：CSB-PA779820
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA779820(RRAD Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA779820(RRAD Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：RRAD
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別名：GTP binding protein RAD antibody; GTP-binding protein RAD antibody; RAD antibody; RAD_HUMAN antibody; RAD1 antibody; RAS (RAD and GEM) like GTP binding 3 antibody; Ras associated with diabetes antibody; Ras related associated with diabetes antibody; REM3 antibody; RRAD antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide of Human RRAD
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
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基因功能參考文獻：
- our study revealed that RRAD expression was decreased in Hepatocellular carcinoma (HCC) tumor tissues and predicted poor clinical outcome for HCC patients and played an important role in regulating aerobic glycolysis and cell invasion and metastasis and may represent potential targets for improving the treatment of HCC PMID: 26546438
- Brg1 inhibits proliferation and migration of human aortic smooth muscle cells by directly up-regulating RRAD in aortic dissection. PMID: 26344687
- RRAD promotes EGFR-mediated STAT3 activation and induces temozolomide resistance of malignant glioblastoma. PMID: 25313011
- RRAD expression is frequently decreased in lung cancer. Ectopic expression of RRAD greatly reduces glycolysis whereas knockdown of RRAD promotes glycolysis in lung cancer cells. PMID: 25114038
- Rad suppresses the NF-Kappa-B mediated transcription and downstream gene activation. Rad can directly bind to RelA/p65 and suppress the interaction of RelA/p65 with the NF-kappa-B response DNA element. PMID: 24632303
- Ras(V12)-mediated oncogenic transformation induces RRAD epigenetic inactivation, which in turn promotes glucose uptake and may contribute to ovarian cancer PMID: 24648519
- RRAD hypermethylation is associated with esophageal squamous cell carcinoma. PMID: 24222170
- Mouse Rad Q65P (the murine equivalent of human Rad Q66P) inhibits L-type currents conducted by CaV1.2 or CaV1.3 channels as potently as wild-type Rad (>95% inhibition of both channels). PMID: 23973784
- Rad over expression could be a molecular target to improve bortezomib sensitivity in human leukemia and lymphoma. PMID: 22658652
- results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development PMID: 22487779
- the implication of oxidative stress in modulating Rad expression, in association with the initiation and progression of amyotrophic lateral sclerosis muscle atrophy PMID: 20079427
- It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 20460530
- crystallization and preliminary crystallographic analysis of human Rad GTPase PMID: 16511212
- Crystal structure of the GTPase domain of human Rad in the GDP-bound form at 1.8 A resolution. PMID: 16866878
- Methylation and gene silencing of the Ras-related GTPase gene is associated with lung and breast cancers PMID: 17195088
- Evidence from Rad transgenic mice suggests that the Rad-associated signaling pathway may play a role in arrhythmogenesis in diverse cardiac diseases. PMID: 17525370
- Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway PMID: 18056528
- occurrence of an unusual TG 3' splice site in intron 1 PMID: 17672918
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亞細胞定位：Cell membrane.
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蛋白家族：Small GTPase superfamily, RGK family
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組織特異性：Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans.
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數據庫鏈接：
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